Genomic Instability and Cancer Genetics Selected Program-Related Publications

Key to Member Program Affiliation


Cancer Metabolism and Immunology
Genomic Instability and Cancer Genetics 
Cancer Pharmacology 
Clinical Investigations and Precision Therapeutics
Cancer Prevention and Control 


Publications with PMCID

Cancer Institute Member(s) Credited

Morgan KM, Fischer BS, Lee FY, Shah JJ, Bertino JR, Rosenfeld J, Singh A, Khiabanian H, Pine SR. Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma. Mol. Cancer Ther. 2017 Dec;16(12):2759-2769. PMID: 28978720; PMCID: PMC5716926.

Bertino JR (CP), Khiabanian H (GICG), Pine SR (GICG)


Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S. Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage. Sci Rep. 2017 Nov 30;7(1):16613. PMID: 29192276; PMCID: PMC5709370.

Xia B (GICG), Ganesan S (CIPT)


Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017 Nov 28;8(1):1823. PMID: 29180628; PMCID: PMC5703960.

Gatza ML (GICG), White E (CMI), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)


Patel DS, Misenko SM, Her J, Bunting SF. BLM helicase regulates DNA repair by counteracting RAD51 loading at DNA double-strand break sites. J. Cell Biol. 2017 Nov 06;216(11):3521-3534. PMID: 28912125; PMCID: PMC5674892.

Bunting SF (GICG)


Smith KS, Liu LL, Ganesan S, Michor F, De S. Nuclear topology modulates the mutational landscapes of cancer genomes. Nat. Struct. Mol. Biol. 2017 Nov;24(11):1000-1006. PMID: 28967881; PMCID: PMC5744871.

Ganesan S (CIPT), De S (GICG)

Droz-Rosario R, Lu H, Liu J, Liu NA, Ganesan S, Xia B, Haffty BG, Shen Z. Roles of BCCIP deficiency in mammary tumorigenesis. Breast Cancer Res. 2017 Oct 18;19(1):115. PMID: 29047390; PMCID: PMC5648485.

Ganesan S (CIPT), Xia B (GICG), Haffty BG (CIPT), Shen Z (GICG)

Liu X, Hoque M, Larochelle M, Lemay JF, Yurko N, Manley JL, Bachand F, Tian B. Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe. Genome Res. 2017 Oct;27(10):1685-1695. PMID: 28916539; PMCID: PMC5630032.

Tian B (GICG)


Przytycki PF, Singh M. Differential analysis between somatic mutation and germline variation profiles reveals cancer-related genes. Genome Med. 2017 08 25;9(1):79. PMID: 28841835; PMCID: PMC5574113.

Singh M (GICG)


Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017 Aug 17;36(33):4750-4766. PMID: 28394342; PMCID: PMC5561484.

Ganesan S (CIPT), White E (CMI), Shen Z (GICG)


Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan VM, Drake JM, Liu L, Boateng MN, Li J, Feng Z, Hu W. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev. 2017 Aug 15;31(16):1641-1654. PMID: 28947497; PMCID: PMC5647935.

Drake JM (CMI), Feng Z (GICG), Hu W (GICG)


Tsang AT, Dudgeon C, Yi L, Yu X, Goraczniak R, Donohue K, Kogan S, Brenneman MA, Ho ES, Gunderson SI, Carpizo DR. U1 Adaptors Suppress the KRAS-MYC Oncogenic Axis in Human Pancreatic Cancer Xenografts. Mol. Cancer Ther. 2017 Aug;16(8):1445-1455. PMID: 28377488; PMCID:PMC5544574.

Gunderson SI (GICG), Carpizo DR (CIPT, CP)


Sharma P, Mullen JR, Li M, Zaratiegui M, Bunting SF, Brill SJ. A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae. Genetics. 2017 08;206(4):1807-1821. PMID: 28550017; PMCID: PMC5560789.

Zaratiegui M (GICG), Bunting SF (GICG), Brill SJ (GICG)


Foo TK, Tischkowitz M, Simhadri S, Boshari T, Zayed N, Burke KA, Berman SH, Blecua P, Riaz N, Huo Y, Ding YC, Neuhausen SL, Weigelt B, Reis-Filho JS, Foulkes WD, Xia B. Compromised BRCA1-PALB2 interaction is associated with breast cancer risk. Oncogene. 2017 Jul 20;36(29):4161-4170. PMID: 28319063; PMCID: PMC5519427.

Xia B (GICG)


Levine AJ, Berger SL. The interplay between epigenetic changes and the p53 protein in stem cells. Genes Dev. 2017 Jun 15;31(12):1195-1201. PMID: 28765161; PMCID: PMC5558922.

Levine AJ (GICG)


Lu K, Alcivar AL, Ma J, Foo TK, Zywea S, Mahdi A, Huo Y, Kensler TW, Gatza ML, Xia B. NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress-Induced DPP3-KEAP1 Interaction. Cancer Res. 2017 Jun 01;77(11):2881-2892. PMID: 28416489; PMCID: PMC5464605.

Gatza ML (GICG), Xia B (GICG)


Tran PLT, Pohl TJ, Chen CF, Chan A, Pott S, Zakian VA. PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes. Nat Commun. 2017 Apr 21;8:15025. PMID: 28429714; PMCID: PMC5413955.

Zakian VA (GICG)


Anantha RW, Simhadri S, Foo TK, Miao S, Liu J, Shen Z, Ganesan S, Xia B. Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance. Elife. 2017 Apr 11;6. PMID: 28398198; PMCID: PMC5432210.

Shen Z (GICG), Ganesan S (CIPT), Xia B (GICG)


Mehta GA, Parker JS, Silva GO, Hoadley KA, Perou CM, Gatza ML. Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer. Breast Cancer Res. Treat. 2017 04;162(3):439-450. PMID: 28176176; PMCID: PMC5334195.

Gatza ML (GICG)


Borrie MS, Campor JS, Joshi H, Gartenberg MR. Binding, sliding, and function of cohesin during transcriptional activation. Proc. Natl. Acad. Sci. U.S.A. 2017 Feb 14;114(7):E1062-E1071. PMID: 28137853; PMCID: PMC5320966.

Gartenberg MR (GICG)


Ramachandran A, Basu U, Sultana S, Nandakumar D, Patel SS. Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation. Nucleic Acids Res. 2017 Jan 25;45(2):861-874. PMID: 27903899; PMCID: PMC5314767.

Patel SS (GICG)


Buisson R, Niraj J, Rodrigue A, Ho CK, Kreuzer J, Foo TK, Hardy EJ, Dellaire G, Haas W, Xia B, Masson JY, Zou L. Coupling of Homologous Recombination and the Checkpoint by ATR. Mol. Cell. 2017 Jan 19;65(2):336-346. PMID: 28089683; PMCID: PMC5496772.

Xia B (GICG)


Tian B, Manley JL. Alternative polyadenylation of mRNA precursors. Nat. Rev. Mol. Cell Biol. 2017 01;18(1):18-30. PMID: 27677860; PMCID: PMC5483950.

Tian B (GICG)


Brennan LD, Forties RA, Patel SS, Wang MD. DNA looping mediates nucleosome transfer. Nat Commun. 2016 Nov 03;7:13337. PMID: 27808093; PMCID: PMC5097161.

Patel SS (GICG)


Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. EMBO Rep. 2016 11;17(11):1532-1541. PMID: 27670884; PMCID: PMC5090706.

Bunting SF (GICG)


Kumar N, Srivillibhuthur M, Joshi S, Walton KD, Zhou A, Faller WJ, Perekatt AO, Sansom OJ, Gumucio DL, Xing J, Bonder EM, Gao N, White E, Verzi MP. A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis. Development. 2016 10 15;143(20):3711-3722. PMID: 27802136; PMCID: PMC5087649.

Gao N (CMI), White E (CMI), Verzi MP (GICG)


Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14;44(18):8855-8869. PMID: 27566146; PMCID: PMC5062998.

Bunting SF (GICG), Zheng XF (CP), Shen Z (GICG), Sabaawy HE (CP), Liu L (CP), Pine SR (GICG)

Dobosz-Bartoszek M, Pinkerton MH, Otwinowski Z, Chakravarthy S, Söll D, Copeland PR, Simonović M. Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation. Nat Commun. 2016 Oct 06;7:12941. PMID: 27708257; PMCID: PMC5059743.

Copeland PR (GICG)


Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev. 2016 Sep 01;30(17):1956-70. PMID: 27664236; PMCID: PMC5066239.

Shen Z (GICG), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)


Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc. Natl. Acad. Sci. U.S.A. 2016 08 23;113(34):E5024-33. PMID: 27503890; PMCID: PMC5003242.

Herbig U (GICG)


Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016 Aug 01;30(15):1704-17. PMID: 27516533; PMCID: PMC5002976.

Guo JY (CMI), Chan CS (GICG), Rabinowitz JD (CMI), White E (CMI)


Vazquez BN, Thackray JK, Simonet NG, Kane-Goldsmith N, Martinez-Redondo P, Nguyen T, Bunting S, Vaquero A, Tischfield JA, Serrano L. SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair. EMBO J. 2016 07 15;35(14):1488-503. PMID: 27225932; PMCID: PMC4884211.

Bunting S (GICG), Tischfield JA (GICG)


Gyuricza MR, Manheimer KB, Apte V, Krishnan B, Joyce EF, McKee BD, McKim KS. Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation. Curr. Biol. 2016 Jul 11;26(13):1688-98. PMID: 27291057; PMCID: PMC4942336.



Roberts AM, Wong AK, Fisk I, Troyanskaya OG. GIANT API: an application programming interface for functional genomics. Nucleic Acids Res. 2016 Jul 08;44(W1):W587-92. PMID: 27098035; PMCID: PMC4987882.

Troyanskaya OG (GICG)


Mehnert JM, Panda A, Zhong H, Hirshfield K, Damare S, Lane K, Sokol L, Stein MN, Rodriguez-Rodriquez L, Kaufman HL, Ali S, Ross JS, Pavlick DC, Bhanot G, White EP, DiPaola RS, Lovell A, Cheng J, Ganesan S. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J. Clin. Invest. 2016 Jun 01;126(6):2334-40. PMID: 27159395; PMCID: PMC4887167.

Mehnert JM (CIPT), Hirshfield K (GICG), Rodriguez-Rodriquez L (CIPT), Kaufman HL (CIPT), Bhanot G (GICG), White EP (CMI), DiPaola RS (CIPT), Ganesan S (CIPT)

Sen D, Patel G, Patel SS. Homologous DNA strand exchange activity of the human mitochondrial DNA helicase TWINKLE. Nucleic Acids Res. 2016 05 19;44(9):4200-10. PMID: 26887820; PMCID: PMC4872091.

Patel SS (GICG)


Marbach-Bar N, Bahat A, Ashkenazi S, Golan-Mashiach M, Haimov O, Wu SY, Chiang CM, Puzio-Kuter A, Hirshfield KM, Levine AJ, Dikstein R. DTIE, a novel core promoter element that directs start site selection in TATA-less genes. Nucleic Acids Res. 2016 Feb 18;44(3):1080-94. PMID: 26464433; PMCID: PMC4756809.

Hirshfield KM (GICG), Levine AJ (GICG)


Wu Q, Paul A, Su D, Mehmood S, Foo TK, Ochi T, Bunting EL, Xia B, Robinson CV, Wang B, Blundell TL. Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites. Mol. Cell. 2016 Feb 04;61(3):434-448. PMID: 26778126; PMCID: PMC4747905.

Xia B (GICG)


Zhou J, Troyanskaya OG. Probabilistic modelling of chromatin code landscape reveals functional diversity of enhancer-like chromatin states. Nat Commun. 2016 Feb 04;7:10528. PMID: 26841971; PMCID: PMC4742914.

Troyanskaya OG (GICG)


Ramanathan A, Devarkar SC, Jiang F, Miller MT, Khan AG, Marcotrigiano J, Patel SS. The autoinhibitory CARD2-Hel2i Interface of RIG-I governs RNA selection. Nucleic Acids Res. 2016 Jan 29;44(2):896-909. PMID: 26612866; PMCID: PMC4737149.

Patel SS (GICG)


Li W, Park JY, Zheng D, Hoque M, Yehia G, Tian B. Alternative cleavage and polyadenylation in spermatogenesis connects chromatin regulation with post-transcriptional control. BMC Biol. 2016 Jan 22;14:6. PMID: 26801249; PMCID: PMC4724118.

Tian B (GICG)


Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife. 2016 Jan 11;5:e10727. PMID: 26751560; PMCID: PMC4749555.

Li S (CMI), Bhanot G (GICG), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)

Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D. A mechanism for the suppression of homologous recombination in G1 cells. Nature. 2015 Dec 17;528(7582):422-6. PMID: 26649820; PMCID: PMC4880051.

Xia B (GICG)


Sun B, Pandey M, Inman JT, Yang Y, Kashlev M, Patel SS, Wang MD. T7 replisome directly overcomes DNA damage. Nat Commun. 2015 Dec 17;6:10260. PMID: 26675048; PMCID: PMC4703881.

Patel SS (GICG)


Tanne A, Muniz LR, Puzio-Kuter A, Leonova KI, Gudkov AV, Ting DT, Monasson R, Cocco S, Levine AJ, Bhardwaj N, Greenbaum BD. Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2015 Dec 08;112(49):15154-9. PMID: 26575629; PMCID: PMC4679042.

Levine AJ (GICG)


da Silva Almeida AC, Abate F, Khiabanian H, Martinez-Escala E, Guitart J, Tensen CP, Vermeer MH, Rabadan R, Ferrando A, Palomero T. The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome. Nat. Genet. 2015 Dec;47(12):1465-70. PMID: 26551667; PMCID: PMC4878831.

Khiabanian H (GICG)


Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS, White E. The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. Cell Rep. 2015 Dec 01;13(9):1895-908. PMID: 26655904; PMCID: PMC4779191.

Ganesan S (CIPT), Chan CS (GICG), White E (CMI)


White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin. Cancer Res. 2015 Nov 15;21(22):5037-46. PMID: 26567363; PMCID: PMC4646728.

White E (CMI), Mehnert JM (CIPT), Chan CS (GICG)

Puzio-Kuter AM, Laddha SV, Castillo-Martin M, Sun Y, Cordon-Cardo C, Chan CS, Levine AJ. Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma. Cell Death Differ. 2015 Nov;22(11):1785-91. PMID: 25822339; PMCID: PMC4648325.

Chan CS (GICG), Levine AJ (GICG)


Zhao Y, Zhang C, Yue X, Li X, Liu J, Yu H, Belyi VA, Yang Q, Feng Z, Hu W. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. Cell Death Differ. 2015 Nov;22(11):1824-36. PMID: 25857266; PMCID: PMC4648328.

Belyi VA (CIPT), Feng Z (GICG), Hu W (GICG)


Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR. Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer. Drug Discov. Today. 2015 Nov;20(11):1391-7. PMID: 26205328; PMCID: PMC4922747.

Levine AJ (GICG), Carpizo DR (CIPT, CP)


Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA, TCGA Research Network, Perou CM. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 2015 Oct 08;163(2):506-19. PMID: 26451490; PMCID: PMC4603750.

Gatza ML (GICG)


Zhou J, Troyanskaya OG. Predicting effects of noncoding variants with deep learning-based sequence model. Nat. Methods. 2015 Oct;12(10):931-4. PMID: 26301843; PMCID: PMC4768299.

Troyanskaya OG (GICG)


Radford SJ, Hoang TL, Głuszek AA, Ohkura H, McKim KS. Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes. PLoS Genet. 2015 Oct;11(10):e1005605. PMID: 26473960; PMCID: PMC4608789.



Jacobs JZ, Rosado-Lugo JD, Cranz-Mileva S, Ciccaglione KM, Tournier V, Zaratiegui M. Arrested replication forks guide retrotransposon integration. Science. 2015 Sep 25;349(6255):1549-53. PMID: 26404838; PMCID: PMC4832573.

Zaratiegui M (GICG)


Lin KW, McDonald KR, Guise AJ, Chan A, Cristea IM, Zakian VA. Proteomics of yeast telomerase identified Cdc48-Npl4-Ufd1 and Ufd4 as regulators of Est1 and telomere length. Nat Commun. 2015 Sep 14;6:8290. PMID: 26365526; PMCID: PMC4579843.

Zakian VA (GICG)


Webb CJ, Zakian VA. Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding. Proc. Natl. Acad. Sci. U.S.A. 2015 Sep 08;112(36):11312-7. PMID: 26305931; PMCID: PMC4568702.

Zakian VA (GICG)


Yue X, Zhao Y, Liu J, Zhang C, Yu H, Wang J, Zheng T, Liu L, Li J, Feng Z, Hu W. BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function. Elife. 2015 Aug 13;4. PMID: 26271008; PMCID: PMC4561369.

Feng Z (GICG), Hu W (GICG)


Goto GH, Zencir S, Hirano Y, Ogi H, Ivessa A, Sugimoto K. Binding of Multiple Rap1 Proteins Stimulates Chromosome Breakage Induction during DNA Replication. PLoS Genet. 2015 Aug;11(8):e1005283. PMID: 26263073; PMCID: PMC4532487.

Sugimoto K (GICG)


Szymanski MR, Kuznetsov VB, Shumate C, Meng Q, Lee YS, Patel G, Patel S, Yin YW. Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase. EMBO J. 2015 Jul 14;34(14):1959-70. PMID: 26056153; PMCID: PMC4547898.

Patel S (GICG)


Pandey M, Elshenawy MM, Jergic S, Takahashi M, Dixon NE, Hamdan SM, Patel SS. Two mechanisms coordinate replication termination by the Escherichia coli Tus-Ter complex. Nucleic Acids Res. 2015 Jul 13;43(12):5924-35. PMID: 26007657; PMCID: PMC4499146.

Patel SS (GICG)


Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L. DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination. Proc. Natl. Acad. Sci. U.S.A. 2015 Jul 07;112(27):E3495-504. PMID: 26100862; PMCID: PMC4500203.

Shen Z (GICG)


Aiyer S, Rossi P, Malani N, Schneider WM, Chandar A, Bushman FD, Montelione GT, Roth MJ. Structural and sequencing analysis of local target DNA recognition by MLV integrase. Nucleic Acids Res. 2015 Jun 23;43(11):5647-63. PMID: 25969444; PMCID: PMC4477651.

Montelione GT (CP), Roth MJ (GICG)


Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG. Understanding multicellular function and disease with human tissue-specific networks. Nat. Genet. 2015 Jun;47(6):569-76. PMID: 25915600; PMCID: PMC4828725.

Troyanskaya OG (GICG)


Nandakumar D, Pandey M, Patel SS. Cooperative base pair melting by helicase and polymerase positioned one nucleotide from each other. Elife. 2015 May 13;4. PMID: 25970034; PMCID: PMC4460406.

Patel SS (GICG)


Li W, You B, Hoque M, Zheng D, Luo W, Ji Z, Park JY, Gunderson SI, Kalsotra A, Manley JL, Tian B. Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation. PLoS Genet. 2015 Apr;11(4):e1005166. PMID: 25906188; PMCID: PMC4407891.

Gunderson SI (GICG), Tian B (GICG)


Phillips JA, Chan A, Paeschke K, Zakian VA. The pif1 helicase, a negative regulator of telomerase, acts preferentially at long telomeres. PLoS Genet. 2015 Apr;11(4):e1005186. PMID: 25906395; PMCID: PMC4408051.

Zakian VA (GICG)


Chen YF, Gartenberg MR. Silencing sounds off. Elife. 2015 Mar 02;4. PMID: 25730674; PMCID: PMC4345821.

Gartenberg MR (GICG)

Zhu Q, Wong AK, Krishnan A, Aure MR, Tadych A, Zhang R, Corney DC, Greene CS, Bongo LA, Kristensen VN, Charikar M, Li K, Troyanskaya OG. Targeted exploration and analysis of large cross-platform human transcriptomic compendia. Nat. Methods. 2015 Mar;12(3):211-4, 3 p following 214. PMID: 25581801; PMCID: PMC4768301.

Troyanskaya OG (GICG)


Nadimpalli S, Persikov AV, Singh M. Pervasive variation of transcription factor orthologs contributes to regulatory network evolution. PLoS Genet. 2015 Mar;11(3):e1005011. PMID: 25748510; PMCID: PMC4351887.

Singh M (GICG)


Persikov AV, Wetzel JL, Rowland EF, Oakes BL, Xu DJ, Singh M, Noyes MB. A systematic survey of the Cys2His2 zinc finger DNA-binding landscape. Nucleic Acids Res. 2015 Feb 18;43(3):1965-84. PMID: 25593323; PMCID: PMC4330361.

Singh M (GICG)


Cicchini M, Karantza V, Xia B. Molecular pathways: autophagy in cancer--a matter of timing and context. Clin. Cancer Res. 2015 Feb 01;21(3):498-504. PMID: 25165101; PMCID: PMC4315744.

Karantza V (CMI), Xia B (GICG)

Stein MN, Hirshfield KM, Zhong H, Singer EA, Ali SM, Ganesan S. Response to crizotinib in a patient with MET-mutant papillary renal cell cancer after progression on tivantinib. Eur. Urol. 2015 Feb;67(2):353-4. PMID: 25457019; PMCID: PMC5500309.

Hirshfield KM (GICG), Singer EA (CIPT), Ganesan S (CIPT)

Liu J, Zhang C, Hu W, Feng Z. Tumor suppressor p53 and its mutants in cancer metabolism. Cancer Lett. 2015 Jan 28;356(2 Pt A):197-203. PMID: 24374014; PMCID: PMC4069248.

Hu W (GICG), Feng Z (GICG)

Amelio I, Inoue S, Markert EK, Levine AJ, Knight RA, Mak TW, Melino G. TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proc. Natl. Acad. Sci. U.S.A. 2015 Jan 06;112(1):226-31. PMID: 25535359; PMCID: PMC4291637.

Markert EK (CIPT), Levine AJ (GICG)


Sabouri N, Capra JA, Zakian VA. The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage. BMC Biol. 2014 Dec 04;12:101. PMID: 25471935; PMCID: PMC4275981.

Zakian VA (GICG)


Dudgeon C, Chan C, Kang W, Sun Y, Emerson R, Robins H, Levine AJ. The evolution of thymic lymphomas in p53 knockout mice. Genes Dev. 2014 Dec 01;28(23):2613-20. PMID: 25452272; PMCID: PMC4248292.

Chan C (GICG), Levine AJ (GICG)


Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W, Feng Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ. 2014 Nov;21(11):1792-804. PMID: 25146927; PMCID: PMC4211364.

Belyi V (CIPT), Hu W (GICG), Feng Z (GICG)


Ariffin H, Hainaut P, Puzio-Kuter A, Choong SS, Chan AS, Tolkunov D, Rajagopal G, Kang W, Lim LL, Krishnan S, Chen KS, Achatz MI, Karsa M, Shamsani J, Levine AJ, Chan CS. Whole-genome sequencing analysis of phenotypic heterogeneity and anticipation in Li-Fraumeni cancer predisposition syndrome. Proc. Natl. Acad. Sci. U.S.A. 2014 Oct 28;111(43):15497-501. PMID: 25313051; PMCID: PMC4217424.

Levine AJ (GICG), Chan CS (GICG)


Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette ZY, Young KH, Liu J, Shen Z, Feng Z, Hu W. LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nat Commun. 2014 Oct 17;5:5218. PMID: 25323535; PMCID: PMC4203416.

Shen Z (GICG), Feng Z (GICG), Hu W (GICG)


Sakamori R, Yu S, Zhang X, Hoffman A, Sun J, Das S, Vedula P, Li G, Fu J, Walker F, Yang CS, Yi Z, Hsu W, Yu DH, Shen L, Rodriguez AJ, Taketo MM, Bonder EM, Verzi MP, Gao N. CDC42 inhibition suppresses progression of incipient intestinal tumors. Cancer Res. 2014 Oct 01;74(19):5480-92. PMID: 25113996; PMCID: PMC4184946.

Yang CS (CMI), Verzi MP (GICG), Gao N (CMI)


Kraushar ML, Thompson K, Wijeratne HR, Viljetic B, Sakers K, Marson JW, Kontoyiannis DL, Buyske S, Hart RP, Rasin MR. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc. Natl. Acad. Sci. U.S.A. 2014 Sep 09;111(36):E3815-24. PMID: 25157170; PMCID: PMC4246959.

Hart RP (CMI), Rasin MR (GICG)


Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B. Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. J. Biol. Chem. 2014 Aug 29;289(35):24617-29. PMID: 25016020; PMCID: PMC4148885.

Ganesan S (CIPT), Bunting SF (GICG), Xia B (GICG)


Dolfi SC, Jäger AV, Medina DJ, Haffty BG, Yang JM, Hirshfield KM. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Aug 01;350(1-2):52-60. PMID: 24747123; PMCID: PMC5500211.

Medina DJ (CIPT), Haffty BG (CIPT), Hirshfield KM (GICG)


Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Autophagy is required for glucose homeostasis and lung tumor maintenance. Cancer Discov. 2014 Aug;4(8):914-27. PMID: 24875857; PMCID: PMC4125614.

Guo JY (CMI), Chan CS (GICG), Rabinowitz JD (CMI), White E (CMI)


Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. J. Exp. Med. 2014 Jun 02;211(6):1027-36. PMID: 24842372; PMCID: PMC4042650.

Bunting S (GICG)


Zheng D, Tian B. Sizing up the poly(A) tail: insights from deep sequencing. Trends Biochem. Sci. 2014 Jun;39(6):255-7. PMID: 24751511; PMCID: PMC4369379.

Tian B (GICG)


Perekatt AO, Valdez MJ, Davila M, Hoffman A, Bonder EM, Gao N, Verzi MP. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. Proc. Natl. Acad. Sci. U.S.A. 2014 May 27;111(21):7695-700. PMID: 24821761; PMCID: PMC4040551.

Gao N (CMI), Verzi MP (GICG)


Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction. Nucleic Acids Res. 2014 May;42(9):5917-28. PMID: 24623816; PMCID: PMC4027182.

Sharma A (CIPT), Montelione GT (CP), Roth MJ (GICG)


Chen M, Gartenberg MR. Coordination of tRNA transcription with export at nuclear pore complexes in budding yeast. Genes Dev. 2014 May 01;28(9):959-70. PMID: 24788517; PMCID: PMC4018494.

Gartenberg MR (GICG)


Zhou R, Zhang J, Bochman ML, Zakian VA, Ha T. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA. Elife. 2014 Apr 29;3:e02190. PMID: 24843019; PMCID: PMC3999857.

Zakian VA (GICG)


Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol. Cancer Res. 2014 Apr;12(4):485-90. PMID: 24478461; PMCID: PMC3989371.

Ganesan S (CIPT), Chan CS (GICG), White E (CMI)

Lozy F, Cai-McRae X, Teplova I, Price S, Reddy A, Bhanot G, Ganesan S, Vazquez A, Karantza V. ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss. Autophagy. 2014 Apr;10(4):662-76. PMID: 24492513; PMCID: PMC4091153.

Bhanot G (GICG), Ganesan S (CIPT), Vazquez A (GICG), Karantza V (CMI)


Jiang P, Singh M. CCAT: Combinatorial Code Analysis Tool for transcriptional regulation. Nucleic Acids Res. 2014 Mar;42(5):2833-47. PMID: 24366875; PMCID: PMC3950699.

Singh M (GICG)


Persikov AV, Rowland EF, Oakes BL, Singh M, Noyes MB. Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common targets. Nucleic Acids Res. 2014 Feb;42(3):1497-508. PMID: 24214968; PMCID: PMC3919609.

Singh M (GICG)


Ghersi D, Singh M. Interaction-based discovery of functionally important genes in cancers. Nucleic Acids Res. 2014 Feb;42(3):e18. PMID: 24362839; PMCID: PMC3919581.

Singh M (GICG)


Bandhu A, Kang J, Fukunaga K, Goto G, Sugimoto K. Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism. PLoS Genet. 2014 Feb;10(2):e1004136. PMID: 24586187; PMCID: PMC3930518.

Sugimoto K (GICG)


Balboula AZ, Schindler K. Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet. 2014 Feb;10(2):e1004194. PMID: 24586209; PMCID: PMC3937256.

Schindler K (GICG)


Bochman ML, Paeschke K, Chan A, Zakian VA. Hrq1, a homolog of the human RecQ4 helicase, acts catalytically and structurally to promote genome integrity. Cell Rep. 2014 Jan 30;6(2):346-56. PMID: 24440721; PMCID: PMC3933191.

Zakian VA (GICG)


Persikov AV, Singh M. De novo prediction of DNA-binding specificities for Cys2His2 zinc finger proteins. Nucleic Acids Res. 2014 Jan;42(1):97-108. PMID: 24097433; PMCID: PMC3874201.

Singh M (GICG)


Guo JY, Xia B, White E. Autophagy-mediated tumor promotion. Cell. 2013 Dec 05;155(6):1216-9. PMID: 24315093; PMCID: PMC3987898.

Guo JY (CMI), Xia B (GICG), White E (CMI)

Huang YY, Dai L, Gaines D, Droz-Rosario R, Lu H, Liu J, Shen Z. BCCIP suppresses tumor initiation but is required for tumor progression. Cancer Res. 2013 Dec 01;73(23):7122-33. PMID: 24145349; PMCID: PMC3918420.

Shen Z (GICG)


Liu W, Jeganathan G, Amiri S, Morgan KM, Ryan BM, Pine SR. Asymmetric segregation of template DNA strands in basal-like human breast cancer cell lines. Mol. Cancer. 2013 Nov 15;12(1):139. PMID: 24238140; PMCID: PMC3866575.

Pine SR (GICG)


Tedeschi PM, Markert EK, Gounder M, Lin H, Dvorzhinski D, Dolfi SC, Chan LL, Qiu J, DiPaola RS, Hirshfield KM, Boros LG, Bertino JR, Oltvai ZN, Vazquez A. Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. Cell Death Dis. 2013 Oct 24;4:e877. PMID: 24157871; PMCID: PMC3920946.

Markert EK (CIPT), DiPaola RS (CIPT), Hirshfield KM (GICG), Bertino JR (CP), Vazquez A (GICG)


Brill SJ. Linking the Enzymes that Unlink DNA. Mol. Cell. 2013 Oct 24;52(2):159-60. PMID: 24210174; PMCID: PMC4126409.

Brill SJ (GICG)

Chen R, Hu T, Mahon GM, Tala I, Pannucci NL, Ozer HL, Whitehead IP. Ubiquitin-mediated interaction of p210 BCR/ABL with β-catenin supports disease progression in a murine model for chronic myelogenous leukemia. Blood. 2013 Sep 19;122(12):2114-24. PMID: 23950177; PMCID: PMC3778552.

Ozer HL (ZY), Whitehead IP (GICG)


Bromberg Y, Kahn PC, Rost B. Neutral and weakly nonneutral sequence variants may define individuality. Proc. Natl. Acad. Sci. U.S.A. 2013 Aug 27;110(35):14255-60. PMID: 23940345; PMCID: PMC3761624.

Bromberg Y (GICG)


Pannucci NL, Li D, Sahay S, Thomas EK, Chen R, Tala I, Hu T, Ciccarelli BT, Megjugorac NJ, Adams Iii HC, Rodriguez PL, Fitzpatrick ER, Lagunoff D, Williams DA, Whitehead IP. Loss of the xeroderma pigmentosum group B protein binding site impairs p210 BCR/ABL1 leukemogenic activity. Blood Cancer J. 2013 Aug 16;3:e135. PMID: 23955590; PMCID: PMC3763389.

Whitehead IP (GICG)


Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov. 2013 Aug;3(8):894-907. PMID: 23650262; PMCID: PMC3740014.

Ganesan S (CIPT), Karantza V (CMI), White E (CMI), Xia B (GICG)


Di Domenico EG, Mattarocci S, Cimino-Reale G, Parisi P, Cifani N, D'Ambrosio E, Zakian VA, Ascenzioni F. Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency. Nucleic Acids Res. 2013 Jul;41(13):6490-500. PMID: 23677619; PMCID: PMC3711455.

Zakian VA (GICG)


Bunting SF, Nussenzweig A. End-joining, translocations and cancer. Nat. Rev. Cancer. 2013 Jul;13(7):443-54. PMID: 23760025; PMCID: PMC5724777.

Bunting SF (GICG)


Schneider WM, Brzezinski JD, Aiyer S, Malani N, Gyuricza M, Bushman FD, Roth MJ. Viral DNA tethering domains complement replication-defective mutations in the p12 protein of MuLV Gag. Proc. Natl. Acad. Sci. U.S.A. 2013 Jun 04;110(23):9487-92. PMID: 23661057; PMCID: PMC3677494.

Roth MJ (GICG)


Webb CJ, Wu Y, Zakian VA. DNA repair at telomeres: keeping the ends intact. Cold Spring Harb Perspect Biol. 2013 Jun 01;5(6). PMID: 23732473; PMCID: PMC3660827.

Zakian VA (GICG)


Paeschke K, Bochman ML, Garcia PD, Cejka P, Friedman KL, Kowalczykowski SC, Zakian VA. Pif1 family helicases suppress genome instability at G-quadruplex motifs. Nature. 2013 May 23;497(7450):458-62. PMID: 23657261; PMCID: PMC3680789.

Zakian VA (GICG)


Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc. Natl. Acad. Sci. U.S.A. 2013 May 21;110(21):8632-7. PMID: 23657012; PMCID: PMC3666744.

Xia B (GICG), Bunting S (GICG)


Goraczniak R, Wall BA, Behlke MA, Lennox KA, Ho ES, Zaphiros NH, Jakubowski C, Patel NR, Zhao S, Magaway C, Subbie SA, Jenny Yu L, Lacava S, Reuhl KR, Chen S, Gunderson SI. U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo. Mol Ther Nucleic Acids. 2013 May 14;2:e92. PMID: 23673539; PMCID: PMC4817935.

Chen S (CP), Gunderson SI (GICG)


Zhang P, Herbig U, Coffman F, Lambert MW. Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage. Nucleic Acids Res. 2013 May 01;41(10):5321-40. PMID: 23571757; PMCID: PMC3664817.

Herbig U (GICG)


Berger B, Peng J, Singh M. Computational solutions for omics data. Nat. Rev. Genet. 2013 May;14(5):333-46. PMID: 23594911; PMCID: PMC3966295.

Singh M (GICG)


Tala I, Chen R, Hu T, Fitzpatrick ER, Williams DA, Whitehead IP. Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression. Leukemia. 2013 Apr;27(5):1080-9. PMID: 23207522; PMCID: PMC3931524.

Whitehead IP (GICG)


Nikkilä J, Parplys AC, Pylkäs K, Bose M, Huo Y, Borgmann K, Rapakko K, Nieminen P, Xia B, Pospiech H, Winqvist R. Heterozygous mutations in PALB2 cause DNA replication and damage response defects. Nat Commun. 2013;4:2578. PMID: 24153426; PMCID: PMC3826652.

Xia B (GICG)


Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, Lin M, Yu H, Liu L, Levine AJ, Hu W, Feng Z. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun. 2013;4:2935. PMID: 24343302; PMCID: PMC3969270.

Levine AJ (GICG), Hu W (GICG), Feng Z (GICG)


Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X, Yu H, Liu L, Feng Z, Hu W. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nat Commun. 2013;4:2996. PMID: 24356649; PMCID: PMC3960723.

Feng Z (GICG), Hu W (GICG)


Ren G, Zhao X, Wang Y, Zhang X, Chen X, Xu C, Yuan ZR, Roberts AI, Zhang L, Zheng B, Wen T, Han Y, Rabson AB, Tischfield JA, Shao C, Shi Y. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα. Cell Stem Cell. 2012 Dec 07;11(6):812-24. PMID: 23168163; PMCID: PMC3518598.

Rabson AB (CMI), Tischfield JA (GICG), Shi Y (CMI)


Bochman ML, Paeschke K, Zakian VA. DNA secondary structures: stability and function of G-quadruplex structures. Nat. Rev. Genet. 2012 Nov;13(11):770-80. PMID: 23032257; PMCID: PMC3725559.

Zakian VA (GICG)


Markert EK, Levine AJ, Vazquez A. Proliferation and tissue remodeling in cancer: the hallmarks revisited. Cell Death Dis. 2012 Oct 04;3:e397. PMID: 23034332; PMCID: PMC3481128.

Markert EK (CIPT), Levine AJ (GICG), Vazquez A (GICG)

Boccardi V, Herbig U. Telomerase gene therapy: a novel approach to combat aging. EMBO Mol Med. 2012 Aug;4(8):685-7. PMID: 22585424; PMCID: PMC3494068.

Herbig U (GICG)


Suram A, Kaplunov J, Patel PL, Ruan H, Cerutti A, Boccardi V, Fumagalli M, Di Micco R, Mirani N, Gurung RL, Hande MP, d'Adda di Fagagna F, Herbig U. Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J. 2012 Jun 29;31(13):2839-51. PMID: 22569128; PMCID: PMC3395091.

Herbig U (GICG)


Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21(5):614-25. PMID: 22624712; PMCID: PMC3366694.

Vazquez A (GICG), Levine AJ (GICG), Carpizo DR (CIPT, CP)

Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine AJ, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2012 May 01;109(18):7013-8. PMID: 22509031; PMCID: PMC3345015.

Feng Z (GICG), Levine AJ (GICG), Hu W (GICG)


Luciano P, Coulon S, Faure V, Corda Y, Bos J, Brill SJ, Gilson E, Simon MN, Géli V. RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts. EMBO J. 2012 Apr 18;31(8):2034-46. PMID: 22354040; PMCID: PMC3343328.

Brill SJ (GICG)


Zhang J, de Toledo SM, Pandey BN, Guo G, Pain D, Li H, Azzam EI. Role of the translationally controlled tumor protein in DNA damage sensing and repair. Proc. Natl. Acad. Sci. U.S.A. 2012 Apr 17;109(16):E926-33. PMID: 22451927; PMCID: PMC3341051.

Li H (CP), Azzam EI (GICG)


Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol. Cell. Biol. 2012 Apr;32(8):1506-17. PMID: 22331464; PMCID: PMC3318596.

Ganesan S (CIPT), Kong AN (CIPT, CP), Xia B (GICG)


Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F. Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat. Cell Biol. 2012 Mar 18;14(4):355-65. PMID: 22426077; PMCID: PMC3717580.

Herbig U (GICG)


Sabouri N, McDonald KR, Webb CJ, Cristea IM, Zakian VA. DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase. Genes Dev. 2012 Mar 15;26(6):581-93. PMID: 22426534; PMCID: PMC3315119.

Zakian VA (GICG)


Benhamed M, Herbig U, Ye T, Dejean A, Bischof O. Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells. Nat. Cell Biol. 2012 Feb 26;14(3):266-75. PMID: 22366686; PMCID: PMC5423543.

Herbig U (GICG)


Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 2012 Jan 20;148(1-2):244-58. PMID: 22265415; PMCID: PMC3511889.

Levine AJ (GICG)


Webb CJ, Zakian VA. Schizosaccharomyces pombe Ccq1 and TER1 bind the 14-3-3-like domain of Est1, which promotes and stabilizes telomerase-telomere association. Genes Dev. 2012 Jan 01;26(1):82-91. PMID: 22215813; PMCID: PMC3258969.

Zakian VA (GICG)


Markert EK, Mizuno H, Vazquez A, Levine AJ. Molecular classification of prostate cancer using curated expression signatures. Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 27;108(52):21276-81. PMID: 22123976; PMCID: PMC3248553.

Markert EK (CIPT), Vazquez A (GICG), Levine AJ (GICG)

Wu Y, Zakian VA. The telomeric Cdc13 protein interacts directly with the telomerase subunit Est1 to bring it to telomeric DNA ends in vitro. Proc. Natl. Acad. Sci. U.S.A. 2011 Dec 20;108(51):20362-9. PMID: 21969561; PMCID: PMC3251085.

Zakian VA (GICG)


Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R. Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence. Dev. Cell. 2011 Dec 13;21(6):1077-91. PMID: 22137763; PMCID: PMC3241855.

Xia B (GICG)


Joyce EF, Pedersen M, Tiong S, White-Brown SK, Paul A, Campbell SD, McKim KS. Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. J. Cell Biol. 2011 Oct 31;195(3):359-67. PMID: 22024169; PMCID: PMC3206348.



Zhang C, Lin M, Wu R, Wang X, Yang B, Levine AJ, Hu W, Feng Z. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc. Natl. Acad. Sci. U.S.A. 2011 Sep 27;108(39):16259-64. PMID: 21930938; PMCID: PMC3182683.

Levine AJ (GICG), Hu W (GICG), Feng Z (GICG)


Lu H, Huang YY, Mehrotra S, Droz-Rosario R, Liu J, Bhaumik M, White E, Shen Z. Essential roles of BCCIP in mouse embryonic development and structural stability of chromosomes. PLoS Genet. 2011 Sep;7(9):e1002291. PMID: 21966279; PMCID: PMC3178617.

White E (CMI), Shen Z (GICG)


Feng Z, Zhang C, Kang HJ, Sun Y, Wang H, Naqvi A, Frank AK, Rosenwaks Z, Murphy ME, Levine AJ, Hu W. Regulation of female reproduction by p53 and its family members. FASEB J. 2011 Jul;25(7):2245-55. PMID: 21402718; PMCID: PMC3114525.

Feng Z (GICG), Levine AJ (GICG), Hu W (GICG)




Publications without PMCID

Cancer Institute Member(s) Credited

Baugh EH, Ke H, Levine AJ, Bonneau RA, Chan CS. Why are there hotspot mutations in the TP53 gene in human cancers? Cell Death Differ. 2018 Jan;25(1):154-160. PMID: 29099487.

Levine AJ (GICG), Chan CS (GICG)

Iglay K, Santorelli ML, Hirshfield KM, Williams JM, Rhoads GG, Lin Y, Demissie K. Impact of Preexisting Mental Illness on All-Cause and Breast Cancer-Specific Mortality in Elderly Patients With Breast Cancer. J. Clin. Oncol. 2017 Dec 20;35(36):4012-4018. PMID: 28934000.

Hirshfield KM (GICG), Demissie K (CPC)


Panda A, Mehnert JM, Hirshfield KM, Riedlinger G, Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L, Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP, Bhanot G, Ganesan S. Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. J. Natl. Cancer Inst. In process 2017 Nov 15. PMID: 29155997.

Mehnert JM (CIPT), Hirshfield KM (GICG), Riedlinger G (CIPT), Poplin E (CIPT), Rodriguez-Rodriguez L (CIPT), Silk AW (CIPT), Aisner J (CIPT), Chan N (CIPT), Malhotra J (CIPT), Kaufman HL (CIPT), White EP (CMI), Bhanot G (GICG), Ganesan S (CIPT)

Hristov BH, Singh M. Network-Based Coverage of Mutational Profiles Reveals Cancer Genes. Cell Syst. 2017 Sep 27;5(3):221-229.e4. PMID: 28957656.

Singh M (GICG)


Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma. Clin. Cancer Res. 2017 Sep 15;23(18):5631-5638. PMID: 28539463.

Hirshfield KM (GICG), Chen S (CP), Pine S (GICG), White E (CMI), Rodriguez-Rodriguez L (CIPT), Mehnert JM (CIPT), Ganesan S (CIPT)

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V. Not just Salk. Science. 2017 09 15;357(6356):1105-1106. PMID: 28912235.

Zakian V (GICG)


Cowen L, Ideker T, Raphael BJ, Sharan R. Network propagation: a universal amplifier of genetic associations. Nat. Rev. Genet. 2017 Sep;18(9):551-562. PMID: 28607512.

Raphael BJ (GICG)


Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H. BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction. J Mol Cell Biol. 2017 Jun 01;9(3):209-219. PMID: 28510697.

Shen Z (GICG)


De S, Ganesan S. Looking beyond drivers and passengers in cancer genome sequencing data. Ann. Oncol. 2017 May 01;28(5):938-945. PMID: 27998972.

De S (GICG), Ganesan S (CIPT)

Krishnan A, Zhang R, Yao V, Theesfeld CL, Wong AK, Tadych A, Volfovsky N, Packer A, Lash A, Troyanskaya OG. Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder. Nat. Neurosci. 2016 Nov;19(11):1454-1462. PMID: 27479844.

Troyanskaya OG (GICG)


Blanden AR, Yu X, Loh SN, Levine AJ, Carpizo DR. Corrigendum to "Reactivating mutant p53 using small molecules as zinc metallochaperones: awakening a sleeping giant in cancer" [Drug Discov. Today 20 (11) (2015) 1391-1397]. Drug Discov. Today. 2016 Oct;21(10):1728. PMID: 27477875.

Levine AJ (GICG), Carpizo DR (CIPT, CP)


Lund PK, Verzi MP. Singling Out Intestinal Epithelial Stem Cells. Gastroenterology. 2016 Aug;151(2):228-31. PMID: 27374365.

Verzi MP (GICG)

Gatza ML, Carey LA. Another Breast Cancer Entity Confirmed: Genomics of Invasive Lobular Breast Cancer. J. Clin. Oncol. 2016 Jun 01;34(16):1838-9. PMID: 27022119.

Gatza ML (GICG)


Zhang X, Schulz R, Edmunds S, Krüger E, Markert E, Gaedcke J, Cormet-Boyaka E, Ghadimi M, Beissbarth T, Levine AJ, Moll UM, Dobbelstein M. MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. Mol. Cell. 2015 Jul 16;59(2):243-57. PMID: 26145175.

Markert E (CIPT), Levine AJ (GICG)


Nandakumar D, Patel SS. Finding the right match fast. Cell. 2015 Feb 26;160(5):809-11. PMID: 25723158.

Patel SS (GICG)

Hait WN, Levine AJ. Genomic complexity: a call to action. Sci Transl Med. 2014 Sep 24;6(255):255cm10. PMID: 25253671.

Levine AJ (GICG)

Ren G, Liu Y, Zhao X, Zhang J, Zheng B, Yuan ZR, Zhang L, Qu X, Tischfield JA, Shao C, Shi Y. Tumor resident mesenchymal stromal cells endow naïve stromal cells with tumor-promoting properties. Oncogene. 2014 Jul 24;33(30):4016-20. PMID: 24077286.

Tischfield JA (GICG), Shi Y (CMI)


Yi L, Lu C, Hu W, Sun Y, Levine AJ. Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation. Cancer Res. 2012 Nov 01;72(21):5635-45. PMID: 22964580.

Hu W (GICG), Levine AJ (GICG)