Clinical Investigations and Precision Therapeutics Selected Program-Related Publications

Key to Member Program Affiliation


Cancer Metabolism and Immunology
Genomic Instability and Cancer Genetics 
Cancer Pharmacology 
Clinical Investigations and Precision Therapeutics
Cancer Prevention and Control 


Publications with PMCID

Cancer Institute Member(s) Credited

Park K, Chen W, Chekmareva MA, Foran DJ, Desai JP. Electromechanical Coupling Factor of Breast Tissue as a Biomarker for Breast Cancer. IEEE Trans Biomed Eng. 2018 Jan;65(1):96-103. PMID: 28436838; PMCID: PMC5648629.

Foran DJ (CIPT)

Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella CA, Gatza ML, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nat Commun. 2017 Nov 28;8(1):1823. PMID: 29180628; PMCID: PMC5703960.

Gatza ML (GICG), White E (CMI), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)

Mehnert JM, Monjazeb AM, Beerthuijzen JMT, Collyar D, Rubinstein L, Harris LN. The Challenge for Development of Valuable Immuno-oncology Biomarkers. Clin. Cancer Res. 2017 09 01;23(17):4970-4979. PMID: 28864725; PMCID: PMC5657536.

Mehnert JM (CIPT)

Khan AJ, Poppe MM, Goyal S, Kokeny KE, Kearney T, Kirstein L, Toppmeyer D, Moore DF, Chen C, Gaffney DK, Haffty BG. Hypofractionated Postmastectomy Radiation Therapy Is Safe and Effective: First Results From a Prospective Phase II Trial. J. Clin. Oncol. 2017 Jun 20;35(18):2037-2043. PMID: 28459606; PMCID: PMC5476174.

Khan AJ (CIPT), Kirstein L (CIPT), Toppmeyer D (CIPT), Haffty BG (CIPT)

Yu X, Blanden A, Tsang AT, Zaman S, Liu Y, Gilleran J, Bencivenga AF, Kimball SD, Loh SN, Carpizo DR. Thiosemicarbazones Functioning as Zinc Metallochaperones to Reactivate Mutant p53. Mol. Pharmacol. 2017 Jun;91(6):567-575. PMID: 28320780; PMCID: PMC5438133.

Carpizo DR (CIPT, CP)

Cruz-Roa A, Gilmore H, Basavanhally A, Feldman M, Ganesan S, Shih NNC, Tomaszewski J, González FA, Madabhushi A. Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent. Sci Rep. 2017 Apr 18;7:46450. PMID: 28418027; PMCID: PMC5394452.

Ganesan S (CIPT), Madabhushi A (CIPT)

Manne SL, Virtue SM, Ozga M, Kashy D, Heckman C, Kissane D, Rosenblum N, Morgan M, Rodriquez L. A comparison of two psychological interventions for newly-diagnosed gynecological cancer patients. Gynecol. Oncol. 2017 Feb;144(2):354-362. PMID: 27887806; PMCID: PMC5239741.

Manne SL (CPC), Rodriquez L (CIPT)

Morgan KM, Riedlinger GM, Rosenfeld J, Ganesan S, Pine SR. Patient- Derived Xenograft Models of Non-Small Cell Lung Cancer and Their Potential Utility in Personalized Medicine. Front Oncol. 2017;7:2. PMID: 28154808; PMCID: PMC5243815.

Riedlinger GM (CIPT), Ganesan S (CIPT), Pine SR (GICG)

Foran DJ, Chen W, Chu H, Sadimin E, Loh D, Riedlinger G, Goodell LA, Ganesan S, Hirshfield K, Rodriguez L, DiPaola RS. Roadmap to a Comprehensive Clinical Data Warehouse for Precision Medicine Applications in Oncology. Cancer Inform. 2017;16:1176935117694349. PMID: 28469389; PMCID: PMC5392017.

Foran DJ (CIPT), Riedlinger G (CIPT), Ganesan S (CIPT), Hirshfield K (GICG), Rodriguez L (CIPT), DiPaola RS (CIPT)

Rojas V, Hirshfield KM, Ganesan S, Rodriguez-Rodriguez L. Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment. Int J Mol Sci. 2016 Dec 15;17(12). PMID: 27983698; PMCID: PMC5187913.

Hirshfield KM (GICG), Ganesan S (CIPT), Rodriguez-Rodriguez L (CIPT)

Bandera EV, Lee VS, Rodriguez-Rodriguez L, Powell CB, Kushi LH. Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival. Clin. Cancer Res. 2016 Dec 01;22(23):5909-5914. PMID: 27521449; PMCID: PMC5135649.

Bandera EV (CPC), Rodriguez-Rodriguez L (CIPT)

Bak MJ, Das Gupta S, Wahler J, Suh N. Role of dietary bioactive natural
products in estrogen receptor-positive breast cancer. Semin. Cancer Biol. 2016 Oct;40-41:170-191. PMID: 27016037; PMCID: PMC5033666.

Suh N (CIPT)

Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol. 2016 Oct;17(10):1374- 1385. PMID: 27592805; PMCID: PMC5587154.

Kaufman HL (CIPT)

Hirshfield KM, Tolkunov D, Zhong H, Ali SM, Stein MN, Murphy S, Vig H, Vazquez A, Glod J, Moss RA, Belyi V, Chan CS, Chen S, Goodell L, Foran D, Yelensky R, Palma NA, Sun JX, Miller VA, Stephens PJ, Ross JS, Kaufman H, Poplin E, Mehnert J, Tan AR, Bertino JR, Aisner J, DiPaola RS, Rodriguez-Rodriguez L, Ganesan S. Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers. Oncologist. In process 2016 Aug 26. PMID: 27566247; PMCID: PMC5189630.

Hirshfield KM (GICG), Vazquez A (GICG), Moss RA (CIPT), Belyi V (CIPT), Chan CS (GICG), Chen S (CP),
Foran D (CIPT), Kaufman H (CIPT), Poplin E (CIPT),
Mehnert J (CIPT), Tan AR (CIPT), Bertino JR (CP),
Aisner J (CIPT), DiPaola RS (CIPT), Rodriguez-Rodriguez L (CIPT), Ganesan S (CIPT)

Pandya HJ, Park K, Chen W, Goodell LA, Foran DJ, Desai JP. Toward a Portable Cancer Diagnostic Tool Using a Disposable MEMS-Based Biochip. IEEE Trans Biomed Eng. 2016 07;63(7):1347-53. PMID: 26930673; PMCID: PMC4917475.

Foran DJ (CIPT)

Mehnert JM, Panda A, Zhong H, Hirshfield K, Damare S, Lane K, Sokol L, Stein MN, Rodriguez-Rodriquez L, Kaufman HL, Ali S, Ross JS, Pavlick DC, Bhanot G, White EP, DiPaola RS, Lovell A, Cheng J, Ganesan S. Immune activation and response to pembrolizumab in POLE-mutant endometrial cancer. J. Clin. Invest. 2016 Jun 01;126(6):2334-40. PMID: 27159395; PMCID: PMC4887167.

Mehnert JM (CIPT), Hirshfield K (GICG), Rodriguez- Rodriquez L (CIPT), Kaufman HL (CIPT), Bhanot G (GICG), White EP (CMI), DiPaola RS (CIPT), Ganesan S (CIPT)

Ali SM, Hensing T, Schrock AB, Allen J, Sanford E, Gowen K, Kulkarni A, He J, Suh JH, Lipson D, Elvin JA, Yelensky R, Chalmers Z, Chmielecki J, Peled N, Klempner SJ, Firozvi K, Frampton GM, Molina JR, Menon S, Brahmer JR, MacMahon H, Nowak J, Ou SH, Zauderer M, Ladanyi M, Zakowski M, Fischbach N, Ross JS, Stephens PJ, Miller VA, Wakelee H, Ganesan S, Salgia R. Comprehensive Genomic Profiling Identifies a Subset of Crizotinib- Responsive ALK-Rearranged Non-Small Cell Lung Cancer Not Detected by Fluorescence In Situ Hybridization. Oncologist. 2016 06;21(6):762-70. PMID: 27245569; PMCID: PMC4912370.

Ganesan S (CIPT)

Li T, Kong AN, Ma Z, Liu H, Liu P, Xiao Y, Jiang X, Wang L. Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant. Oncotarget. 2016 Apr 12;7(15):20236-48. PMID: 26934120; PMCID: PMC4991450.

Kong AN (CIPT, CP)

McMasters KM, Egger ME, Edwards MJ, Ross MI, Reintgen DS, Noyes RD, Martin RC, Goydos JS, Beitsch PD, Urist MM, Ariyan S, Sussman JJ, Davidson BS, Gershenwald JE, Hagendoorn LJ, Stromberg AJ, Scoggins CR. Final Results of the Sunbelt Melanoma Trial: A Multi-Institutional Prospective Randomized Phase III Study Evaluating the Role of Adjuvant High-Dose Interferon Alfa-2b and Completion Lymph Node Dissection for Patients Staged by Sentinel Lymph Node Biopsy. J. Clin. Oncol. 2016 Apr 01;34(10):1079-86. PMID: 26858331; PMCID: PMC5321066.

Goydos JS (CIPT)

Santanam U, Banach-Petrosky W, Abate-Shen C, Shen MM, White E, DiPaola RS. Atg7 cooperates with Pten loss to drive prostate cancer tumor growth. Genes Dev. 2016 Feb 15;30(4):399-407. PMID: 26883359; PMCID: PMC4762425.

White E (CMI), DiPaola RS (CIPT)

Stein MN, Hussain M, Stadler WM, Liu G, Tereshchenko IV, Goodin S, Jeyamohan C, Kaufman HL, Mehnert J, DiPaola RS. A Phase II Study of AT- 101 to Overcome Bcl-2--Mediated Resistance to Androgen Deprivation Therapy in Patients With Newly Diagnosed Castration-Sensitive Metastatic Prostate Cancer. Clin Genitourin Cancer. 2016 Feb;14(1):22-7. PMID: 26476589; PMCID: PMC4698193.

Goodin S (CIPT), Kaufman HL (CIPT), Mehnert J (CIPT),
DiPaola RS (CIPT)

Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife. 2016 Jan 11;5:e10727. PMID: 26751560; PMCID: PMC4749555.

Li S (CMI), Bhanot G (GICG), Haffty BG (CIPT), Hu W (GICG), Feng Z (GICG)

Eng OS, Arlow RL, Moore D, Chen C, Langenfeld JE, August DA, Carpizo DR. Fluid administration and morbidity in transhiatal esophagectomy. J. Surg. Res. 2016 Jan;200(1):91-7. PMID: 26319974; PMCID: PMC4914131.

Langenfeld JE (CIPT), Carpizo DR (CIPT, CP)

Diab N, Clark G, Langer L, Wang Y, Hamlington B, Brzeskiewicz L, O'Shaughnessy J, Diab S, Jabbour SK. Impact of race and tumor subtype on second malignancy risk in women with breast cancer. Springerplus. 2016;5:14. PMID: 26759753; PMCID: PMC4703603.

Jabbour SK (CIPT)

Bartucci M, Ferrari AC, Kim IY, Ploss A, Yarmush M, Sabaawy HE. Personalized Medicine Approaches in Prostate Cancer Employing Patient Derived 3D Organoids and Humanized Mice. Front Cell Dev Biol. 2016;4:64. PMID: 27446916; PMCID: PMC4917534.

Ferrari AC (CIPT), Kim IY (CIPT), Ploss A (CMI), Yarmush M (CP), Sabaawy HE (CP)

La Porta J, Matus-Nicodemos R, Valentín-Acevedo A, Covey LR. The RNA- Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation. PLoS ONE. 2016;11(8):e0158708. PMID: 27513449; PMCID: PMC4981342.

Covey LR (CIPT)

Kurc T, Qi X, Wang D, Wang F, Teodoro G, Cooper L, Nalisnik M, Yang L, Saltz J, Foran DJ. Scalable analysis of Big pathology image data cohorts using efficient methods and high-performance computing strategies. BMC Bioinformatics. 2015 Dec 01;16:399. PMID: 26627175; PMCID: PMC4667532.

Foran DJ (CIPT)

White E, Mehnert JM, Chan CS. Autophagy, Metabolism, and Cancer. Clin.
Cancer Res. 2015 Nov 15;21(22):5037-46. PMID: 26567363; PMCID: PMC4646728.

White E (CMI), Mehnert JM (CIPT), Chan CS (GICG)

Higgins LM, Zevon M, Ganapathy V, Sheng Y, Tan MC, Riman RE, Roth CM, Moghe PV, Pierce MC. Line-scanning confocal microscopy for high-resolution imaging of upconverting rare-earth-based contrast agents. J Biomed Opt. 2015 Nov;20(11):110506. PMID: 26603495; PMCID: PMC4874057.

Roth CM (CP), Moghe PV (CP), Pierce MC (CIPT)

Chen W, Brandes Z, Roy R, Chekmareva M, Pandya HJ, Desai JP, Foran DJ. Robot-Guided Atomic Force Microscopy for Mechano-Visual Phenotyping of Cancer Specimens. Microsc. Microanal. 2015 Oct;21(5):1224-35. PMID: 26343283; PMCID: PMC4729564.

Foran DJ (CIPT)

DiPaola RS, Chen YH, Bubley GJ, Stein MN, Hahn NM, Carducci MA, Lattime EC, Gulley JL, Arlen PM, Butterfield LH, Wilding G. A national multicenter phase 2 study of prostate-specific antigen (PSA) pox virus vaccine with sequential androgen ablation therapy in patients with PSA progression: ECOG 9802. Eur. Urol. 2015 Sep;68(3):365-71. PMID: 25533418; PMCID: PMC4472612.

DiPaola RS (CIPT), Lattime EC (CMI)

Hussain M, Rathkopf D, Liu G, Armstrong A, Kelly WK, Ferrari A, Hainsworth J, Joshi A, Hozak RR, Yang L, Schwartz JD, Higano CS. A randomised non- comparative phase II trial of cixutumumab (IMC-A12) or ramucirumab (IMC-1121B) plus mitoxantrone and prednisone in men with metastatic docetaxel- pretreated castration-resistant prostate cancer. Eur. J. Cancer. 2015 Sep;51(13):1714-24. PMID: 26082390; PMCID: PMC5024789.

Ferrari A (CIPT)

Yue W, Zheng X, Lin Y, Yang CS, Xu Q, Carpizo D, Huang H, DiPaola RS, Tan XL. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2. Oncotarget. 2015 Aug 28;6(25):21208-24. PMID: 26056043; PMCID: PMC4673260.

Zheng X (CIPT), Yang CS (CMI), Carpizo D (CIPT, CP), DiPaola RS (CIPT), Tan XL (CPC)

Sweeney CJ, Chen YH, Carducci M, Liu G, Jarrard DF, Eisenberger M, Wong YN, Hahn N, Kohli M, Cooney MM, Dreicer R, Vogelzang NJ, Picus J, Shevrin D, Hussain M, Garcia JA, DiPaola RS. Chemohormonal Therapy in Metastatic Hormone-Sensitive Prostate Cancer. N. Engl. J. Med. 2015 Aug 20;373(8):737-46. PMID: 26244877; PMCID: PMC4562797.

DiPaola RS (CIPT)

Rugo HS, Barry WT, Moreno-Aspitia A, Lyss AP, Cirrincione C, Leung E, Mayer EL, Naughton M, Toppmeyer D, Carey LA, Perez EA, Hudis C, Winer EP. Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N063H (Alliance). J. Clin. Oncol. 2015 Jul 20;33(21):2361-9. PMID: 26056183; PMCID: PMC4500830.

Toppmeyer D (CIPT)

Bjørklund SS, Kristensen VN, Seiler M, Kumar S, Alnæs GI, Ming Y, Kerrigan J, Naume B, Sachidanandam R, Bhanot G, Børresen-Dale AL, Ganesan S. Expression of an estrogen-regulated variant transcript of the peroxisomal branched chain fatty acid oxidase ACOX2 in breast carcinomas. BMC Cancer. 2015 Jul 17;15:524. PMID: 26183823; PMCID: PMC4504068.

Bhanot G (GICG), Ganesan S (CIPT)

Bansal N, Mishra PJ, Stein M, DiPaola RS, Bertino JR. Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells. Oncotarget. 2015 Jun 20;6(17):15321-31. PMID: 26036314; PMCID: PMC4558154.

DiPaola RS (CIPT), Bertino JR (CP)

Teh JL, Shah R, La Cava S, Dolfi SC, Mehta MS, Kongara S, Price S, Ganesan S, Reuhl KR, Hirshfield KM, Karantza V, Chen S. Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells. Breast Cancer Res. Treat. 2015 May;151(1):57-73. PMID: 25859923; PMCID: PMC5193007.

Ganesan S (CIPT), Hirshfield KM (GICG), Karantza V (CMI), Chen S (CP)

Xie X, Koh JY, Price S, White E, Mehnert JM. Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov. 2015 Apr;5(4):410-23. PMID: 25673642; PMCID: PMC4390491.

White E (CMI), Mehnert JM (CIPT)

Ahmed I, Ferro A, Cohler A, Langenfeld J, Surakanti SG, Aisner J, Zou W, Haffty BG, Jabbour SK. Impact of metformin use on survival in locally- advanced, inoperable non-small cell lung cancer treated with definitive chemoradiation. J Thorac Dis. 2015 Mar;7(3):346-55. PMID: 25922712; PMCID: PMC4387400.

Langenfeld J (CIPT), Aisner J (CIPT), Haffty BG (CIPT),
Jabbour SK (CIPT)

Stein MN, Hirshfield KM, Zhong H, Singer EA, Ali SM, Ganesan S. Response to crizotinib in a patient with MET-mutant papillary renal cell cancer after progression on tivantinib. Eur. Urol. 2015 Feb;67(2):353-4. PMID: 25457019; PMCID: PMC5500309.

Hirshfield KM (GICG), Singer EA (CIPT), Ganesan S (CIPT)

Kohlhapp FJ, Broucek JR, Hughes T, Huelsmann EJ, Lusciks J, Zayas JP, Dolubizno H, Fleetwood VA, Grin A, Hill GE, Poshepny JL, Nabatiyan A, Ruby CE, Snook JD, Rudra JS, Schenkel JM, Masopust D, Zloza A, Kaufman HL. NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade. J Immunother Cancer. 2015;3:18. PMID: 25992289; PMCID: PMC4437746.

Zloza A (CIPT), Kaufman HL (CIPT)

Guo Y, Lee JH, Shu L, Huang Y, Li W, Zhang C, Yang AY, Boyanapalli SS, Perekatt A, Hart RP, Verzi M, Kong AN. Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq. Cell Biosci. 2015;5:24. PMID: 26101583; PMCID: PMC4476183.

Hart RP (CMI), Verzi M (GICG), Kong AN (CIPT, CP)

Pandya HJ, Park K, Chen W, Chekmareva MA, Foran DJ, Desai JP. Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer. Lab Chip. 2015;15(18):3695-706. PMID: 26224116; PMCID: PMC4550491.

Foran DJ (CIPT)

Wu Y, Kwon YS, Labib M, Foran DJ, Singer EA. Magnetic Resonance Imaging as a Biomarker for Renal Cell Carcinoma. Dis. Markers. 2015;2015:648495. PMID: 26609190; PMCID: PMC4644550.

Foran DJ (CIPT), Singer EA (CIPT)

Huang H, Chen X, Li D, He Y, Li Y, Du Z, Zhang K, DiPaola R, Goodin S, Zheng X. Combination of α-Tomatine and Curcumin Inhibits Growth and Induces Apoptosis in Human Prostate Cancer Cells. PLoS ONE. 2015;10(12):e0144293. PMID: 26630272; PMCID: PMC4668011.

DiPaola R (CIPT), Goodin S (CIPT), Zheng X (CIPT)

Su H, Shen Y, Xing F, Qi X, Hirshfield KM, Yang L, Foran DJ. Robust automatic breast cancer staging using a combination of functional genomics and image-omics. Conf Proc IEEE Eng Med Biol Soc. 2015;2015:7226-9. PMID: 26737959; PMCID: PMC4918467.

Hirshfield KM (GICG), Foran DJ (CIPT)

Wu H, Schiff DS, Lin Y, Neboori HJ, Goyal S, Feng Z, Haffty BG. Ionizing radiation sensitizes breast cancer cells to Bcl-2 inhibitor, ABT-737, through regulating Mcl-1. Radiat. Res. 2014 Dec;182(6):618-25. PMID: 25409124; PMCID: PMC5523983.

Feng Z (GICG), Haffty BG (CIPT)

Tereshchenko IV, Zhong H, Chekmareva MA, Kane-Goldsmith N, Santanam U, Petrosky W, Stein MN, Ganesan S, Singer EA, Moore D, Tischfield JA, DiPaola RS. ERG and CHD1 heterogeneity in prostate cancer: use of confocal microscopy in assessment of microscopic foci. Prostate. 2014 Nov;74(15):1551-9. PMID: 25175909; PMCID: PMC4181586.

Ganesan S (CIPT), Singer EA (CIPT), Tischfield JA (GICG), DiPaola RS (CIPT)

Yu X, Blanden AR, Narayanan S, Jayakumar L, Lubin D, Augeri D, Kimball SD, Loh SN, Carpizo DR. Small molecule restoration of wildtype structure and function of mutant p53 using a novel zinc-metallochaperone based mechanism. Oncotarget. 2014 Oct 15;5(19):8879-92. PMID: 25294809; PMCID: PMC4253404.

Augeri D (CP), Carpizo DR (CIPT, CP)

Qi X, Wang D, Rodero I, Diaz-Montes J, Gensure RH, Xing F, Zhong H, Goodell L, Parashar M, Foran DJ, Yang L. Content-based histopathology image retrieval using CometCloud. BMC Bioinformatics. 2014 Aug 26;15:287. PMID: 25155691; PMCID: PMC4161917.

Parashar M (CIPT), Foran DJ (CIPT)

Dolfi SC, Jäger AV, Medina DJ, Haffty BG, Yang JM, Hirshfield KM. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Aug 01;350(1-2):52-60. PMID: 24747123; PMCID: PMC5500211.

Medina DJ (CIPT), Haffty BG (CIPT), Hirshfield KM (GICG)

Higgins LM, Pierce MC. Design and characterization of a handheld multimodal imaging device for the assessment of oral epithelial lesions. J Biomed Opt. 2014 Aug;19(8):086004. PMID: 25104410; PMCID: PMC4125204.

Pierce MC (CIPT)

Glod J, Song M, Sharma A, Tyagi R, Rhodes RH, Weissmann DJ, Roychowdhury S, Khan A, Kane MP, Hirshfield K, Ganesan S, DiPaola RS, Rodriguez-Rodriguez L. Next generation sequencing as an aid to diagnosis and treatment of an unusual pediatric brain cancer. J Pers Med. 2014 Jul 15;4(3):402-11. PMID: 25563358; PMCID: PMC4263965.

Sharma A (CIPT), Khan A (CIPT), Hirshfield K (GICG), Ganesan S (CIPT), DiPaola RS (CIPT), Rodriguez- Rodriguez L (CIPT)

Wan L, Lu X, Yuan S, Wei Y, Guo F, Shen M, Yuan M, Chakrabarti R, Hua Y, Smith HA, Blanco MA, Chekmareva M, Wu H, Bronson RT, Haffty BG, Xing Y, Kang Y. MTDH-SND1 interaction is crucial for expansion and activity of tumor- initiating cells in diverse oncogene- and carcinogen-induced mammary tumors. Cancer Cell. 2014 Jul 14;26(1):92-105. PMID: 24981741; PMCID: PMC4101059.

Haffty BG (CIPT), Kang Y (CMI)

Chen W, Wong C, Vosburgh E, Levine AJ, Foran DJ, Xu EY. High- throughput image analysis of tumor spheroids: a user-friendly software application to measure the size of spheroids automatically and accurately. J Vis Exp. 2014 Jul 08;(89). PMID: 25046278; PMCID: PMC4212916.

Levine AJ (GICG), Foran DJ (CIPT), Xu EY (GICG)

Wu Y, Lin Y, Lu SE, Li CS, Shih WJ. Extension of a Cox proportional hazards cure model when cure information is partially known. Biostatistics. 2014 Jul;15(3):540-54. PMID: 24511081; PMCID: PMC4059463.

Shih WJ (CIPT)

Teh JL, Shah R, Shin SS, Wen Y, Mehnert JM, Goydos J, Chen S. Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor. Pigment Cell Melanoma Res. 2014 Jul;27(4):621-9. PMID: 24628914; PMCID: PMC4061214.

Mehnert JM (CIPT), Goydos J (CIPT), Chen S (CP)

Grant SB, Modi PK, Singer EA. Futility and the care of surgical patients: ethical dilemmas. World J Surg. 2014 Jul;38(7):1631-7. PMID: 24849199; PMCID: PMC5176346.

Singer EA (CIPT)

Pillai RN, Aisner J, Dahlberg SE, Rogers JS, DiPaola RS, Aisner S, Ramalingam SS, Schiller JH. Interferon alpha plus 13-cis-retinoic acid modulation of BCL-2 plus paclitaxel for recurrent small-cell lung cancer (SCLC): an Eastern Cooperative Oncology Group study (E6501). Cancer Chemother. Pharmacol. 2014 Jul;74(1):177-83. PMID: 24858462; PMCID: PMC4296897.

Aisner J (CIPT), DiPaola RS (CIPT)

Ding N, Cui XX, Gao Z, Huang H, Wei X, Du Z, Lin Y, Shih WJ, Rabson AB, Conney AH, Hu C, Zheng X. A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors. Int. J. Oncol. 2014 Jun;44(6):2139-45. PMID: 24647860; PMCID: PMC4063540.

Shih WJ (CIPT), Rabson AB (CMI), Conney AH (CMI),
Zheng X (CIPT)

Wen Y, Li J, Koo J, Shin SS, Lin Y, Jeong BS, Mehnert JM, Chen S, Cohen- Sola KA, Goydos JS. Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression. Cancer Res. 2014 May 01;74(9):2499-509. PMID: 24491800; PMCID: PMC4008638.

Mehnert JM (CIPT), Chen S (CP), Goydos JS (CIPT)

Laddha SV, Ganesan S, Chan CS, White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol. Cancer Res. 2014 Apr;12(4):485-90. PMID: 24478461; PMCID: PMC3989371.

Ganesan S (CIPT), Chan CS (GICG), White E (CMI)

Lozy F, Cai-McRae X, Teplova I, Price S, Reddy A, Bhanot G, Ganesan S, Vazquez A, Karantza V. ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss. Autophagy. 2014 Apr;10(4):662-76. PMID: 24492513; PMCID: PMC4091153.

Bhanot G (GICG), Ganesan S (CIPT), Vazquez A (GICG),
Karantza V (CMI)

Wall BA, Wangari-Talbot J, Shin SS, Schiff D, Sierra J, Yu LJ, Khan A, Haffty B, Goydos JS, Chen S. Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells. Pigment Cell Melanoma Res. 2014 Mar;27(2):263-74. PMID: 24330389; PMCID: PMC3947419.

Khan A (CIPT), Haffty B (CIPT), Goydos JS (CIPT),
Chen S (CP)

Wang H, Cui XX, Goodin S, Ding N, Van Doren J, Du Z, Huang MT, Liu Y, Cheng X, Dipaola RS, Conney AH, Zheng X. Inhibition of IL-6 expression in LNCaP prostate cancer cells by a combination of atorvastatin and celecoxib. Oncol. Rep. 2014 Feb;31(2):835-41. PMID: 24296978; PMCID: PMC3981114.

Goodin S (CIPT), Dipaola RS (CIPT), Conney AH (CMI),
Zheng X (CIPT)

Wieder R, Delarosa N, Bryan M, Hill AM, Amadio WJ. Prescription coverage in indigent patients affects the use of long-acting opioids in the management of
cancer pain. Pain Med. 2014 Jan;15(1):42-51. PMID: 24106748; PMCID: PMC3947034.

Wieder R (CIPT)

Medina DJ, Abass-Shereef J, Walton K, Goodell L, Aviv H, Strair RK, Budak- Alpdogan T. Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS ONE. 2014;9(4):e91042. PMID: 24722054; PMCID: PMC3982953.

Medina DJ (CIPT), Strair RK (CIPT)

Margaliot M, Sontag ED, Tuller T. Entrainment to periodic initiation and transition rates in a computational model for gene translation. PLoS ONE. 2014;9(5):e96039. PMID: 24800863; PMCID: PMC4011696.

Sontag ED (CIPT)

So JY, Lin JJ, Wahler J, Liby KT, Sporn MB, Suh N. A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer. PLoS ONE. 2014;9(9):e107616. PMID: 25229616; PMCID: PMC4167992.

Suh N (CIPT)

Kulkarni A, Oza J, Yao M, Sohail H, Ginjala V, Tomas-Loba A, Horejsi Z, Tan AR, Boulton SJ, Ganesan S. Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. J. Biol. Chem. 2013 Nov 08;288(45):32357-69. PMID: 23926104; PMCID: PMC3820871.

Tan AR (CIPT), Ganesan S (CIPT)

Nemunaitis JJ, Small KA, Kirschmeier P, Zhang D, Zhu Y, Jou YM, Statkevich P, Yao SL, Bannerji R. A first-in-human, phase 1, dose-escalation study of dinaciclib, a novel cyclin-dependent kinase inhibitor, administered weekly in subjects with advanced malignancies. J Transl Med. 2013 Oct 16;11:259. PMID: 24131779; PMCID: PMC3853718.

Bannerji R (CIPT)

Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Kuerer HM, Bowling M, Flippo-Morton TS, Byrd DR, Ollila DW, Julian TB, McLaughlin SA, McCall L, Symmans WF, Le-Petross HT, Haffty BG, Buchholz TA, Nelson H, Hunt KK, Alliance for Clinical Trials in Oncology. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013 Oct 09;310(14):1455-61. PMID: 24101169; PMCID: PMC4075763.

Haffty BG (CIPT)

Huo Y, Cai H, Teplova I, Bowman-Colin C, Chen G, Price S, Barnard N, Ganesan S, Karantza V, White E, Xia B. Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov. 2013 Aug;3(8):894-907. PMID: 23650262; PMCID: PMC3740014.

Ganesan S (CIPT), Karantza V (CMI), White E (CMI), Xia B (GICG)

Barboza N, Minakhina S, Medina DJ, Balsara B, Greenwood S, Huzzy L, Rabson AB, Steward R, Schaar DG. PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia. Cancer Biol. Ther. 2013 Jun;14(6):546-55. PMID: 23760497; PMCID: PMC3813571.

Medina DJ (CIPT), Rabson AB (CMI), Steward R (CMI), Schaar DG (CIPT)

Pharoah PD, Tsai YY, Ramus SJ, Phelan CM, Goode EL, Lawrenson K, Buckley M, Fridley BL, Tyrer JP, Shen H, Weber R, Karevan R, Larson MC, Song H, Tessier DC, Bacot F, Vincent D, Cunningham JM, Dennis J, Dicks E, Australian Cancer Study, Australian Ovarian Cancer Study Group, Aben KK, Anton-Culver H, Antonenkova N, Armasu SM, Baglietto L, Bandera EV, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brenton JD, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Campbell I, Carney ME, Carvalho RS, Chang-Claude J, Chen YA, Chen Z, Chow WH, Cicek MS, Coetzee G, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Despierre E, Doherty JA, Dörk T, du Bois A, Dürst M, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher D, Flanagan J, Gao YT, Garcia-Closas M, Gentry-Maharaj A, Giles G, Gjyshi A, Gore M, Gronwald J, Guo Q, Halle MK, Harter P, Hein A, Heitz F, Hillemanns P, Hoatlin M, Høgdall E, Høgdall CK, Hosono S, Jakubowska A, Jensen A, Kalli KR, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Konecny GE, Krakstad C, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee N, Lee J, Leminen A, Lim BK, Lissowska J, Lubiński J, Lundvall L, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson S, Orlow I, Paul J, Pejovic T, Pelttari LM, Permuth-Wey J, Pike MC, Poole EM, Qu X, Risch HA, Rodriguez-Rodriguez L, Rossing MA, Rudolph A, Runnebaum I, Rzepecka IK, Salvesen HB, Schwaab I, Severi G, Shen H, Shridhar V, Shu XO, Sieh W, Southey MC, Spellman P, Tajima K, Teo SH, Terry KL, Thompson PJ, Timorek A, Tworoger SS, van Altena AM, van den Berg D, Vergote I, Vierkant RA, Vitonis AF, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wik E, Winterhoff B, Woo YL, Wu AH, Yang HP, Zheng W, Ziogas A, Zulkifli F, Goodman MT, Hall P, Easton DF, Pearce CL, Berchuck A, Chenevix-Trench G, Iversen E, Monteiro AN, Gayther SA, Schildkraut JM, Sellers TA. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat. Genet. 2013 Apr;45(4):362-70, 370e1-2. PMID: 23535730; PMCID: PMC3693183.

Bandera EV (CPC), Rodriguez-Rodriguez L (CIPT)

Bojesen SE, Pooley KA, Johnatty SE, Beesley J, Michailidou K, Tyrer JP, Edwards SL, Pickett HA, Shen HC, Smart CE, Hillman KM, Mai PL, Lawrenson K, Stutz MD, Lu Y, Karevan R, Woods N, Johnston RL, French JD, Chen X, Weischer M, Nielsen SF, Maranian MJ, Ghoussaini M, Ahmed S, Baynes C, Bolla MK, Wang Q, Dennis J, McGuffog L, Barrowdale D, Lee A, Healey S, Lush M, Tessier DC, Vincent D, Bacot F, Australian Cancer Study, Australian Ovarian Cancer Study, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Gene Environment Interaction and Breast Cancer (GENICA), Swedish Breast Cancer Study (SWE-BRCA), Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE), Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), Vergote I, Lambrechts S, Despierre E, Risch HA, Armasu SM, Schmidt MK, Braaf LM, Winterhoff B, Nevanlinna H, Konecny GE, Lambrechts D, Rogmann L, Guénel P, Teoman A, Milne RL, Garcia JJ, Cox A, Shridhar V, Burwinkel B, Marme F, Hein R, Sawyer EJ, Haiman CA, Wang- Gohrke S, Andrulis IL, Moysich KB, Hopper JL, Odunsi K, Lindblom A, Giles GG, Brenner H, Simard J, Lurie G, Fasching PA, Carney ME, Radice P, Wilkens LR, Swerdlow A, Goodman MT, Brauch H, Garcia-Closas M, Hillemanns P, Winqvist R, Dürst M, Devilee P, Runnebaum I, Jakubowska A, Lubinski J, Mannermaa A, Butzow R, Bogdanova NV, Dörk T, Pelttari LM, Zheng W, Leminen A, Anton-Culver H, Bunker CH, Kristensen V, Ness RB, Muir K, Edwards R, Meindl A, Heitz F, Matsuo K, du Bois A, Wu AH, Harter P, Teo SH, Schwaab I, Shu XO, Blot W, Hosono S, Kang D, Nakanishi T, Hartman M, Yatabe Y, Hamann U, Karlan BY, Sangrajrang S, Kjaer SK, Gaborieau V, Jensen A, Eccles D, Høgdall E, Shen CY, Brown J, Woo YL, Shah M, Azmi MA, Luben R, Omar SZ, Czene K, Vierkant RA, Nordestgaard BG, Flyger H, Vachon C, Olson JE, Wang X, Levine DA, Rudolph A, Weber RP, Flesch-Janys D, Iversen E, Nickels S, Schildkraut JM, Silva Idos S, Cramer DW, Gibson L, Terry KL, Fletcher O, Vitonis AF, van der Schoot CE, Poole EM, Hogervorst FB, Tworoger SS, Liu J, Bandera EV, Li J, Olson SH, Humphreys K, Orlow I, Blomqvist C, Rodriguez-Rodriguez L, Aittomäki K, Salvesen HB, Muranen TA, Wik E, Brouwers B, Krakstad C, Wauters E, Halle MK, Wildiers H, Kiemeney LA, Mulot C, Aben KK, Laurent-Puig P, Altena AM, Truong T, Massuger LF, Benitez J, Pejovic T, Perez JI, Hoatlin M, Zamora MP, Cook LS, Balasubramanian SP, Kelemen LE, Schneeweiss A, Le ND, Sohn C, Brooks-Wilson A, Tomlinson I, Kerin MJ, Miller N, Cybulski C, Henderson BE, Menkiszak J, Schumacher F, Wentzensen N, Le Marchand L, Yang HP, Mulligan AM, Glendon G, Engelholm SA, Knight JA, Høgdall CK, Apicella C, Gore M, Tsimiklis H, Song H, Southey MC, Jager A, den Ouweland AM, Brown R, Martens JW, Flanagan JM, Kriege M, Paul J, Margolin S, Siddiqui N, Severi G, Whittemore AS, Baglietto L, McGuire V, Stegmaier C, Sieh W, Müller H, Arndt V, Labrèche F, Gao YT, Goldberg MS, Yang G, Dumont M, McLaughlin JR, Hartmann A, Ekici AB, Beckmann MW, Phelan CM, Lux MP, Permuth-Wey J, Peissel B, Sellers TA, Ficarazzi F, Barile M, Ziogas A, Ashworth A, Gentry- Maharaj A, Jones M, Ramus SJ, Orr N, Menon U, Pearce CL, Brüning T, Pike MC, Ko YD, Lissowska J, Figueroa J, Kupryjanczyk J, Chanock SJ, Dansonka- Mieszkowska A, Jukkola-Vuorinen A, Rzepecka IK, Pylkäs K, Bidzinski M, Kauppila S, Hollestelle A, Seynaeve C, Tollenaar RA, Durda K, Jaworska K, Hartikainen JM, Kosma VM, Kataja V, Antonenkova NN, Long J, Shrubsole M, Deming-Halverson S, Lophatananon A, Siriwanarangsan P, Stewart-Brown S, Ditsch N, Lichtner P, Schmutzler RK, Ito H, Iwata H, Tajima K, Tseng CC, Stram DO, van den Berg D, Yip CH, Ikram MK, Teh YC, Cai H, Lu W, Signorello LB, Cai Q, Noh DY, Yoo KY, Miao H, Iau PT, Teo YY, McKay J, Shapiro C, Ademuyiwa F, Fountzilas G, Hsiung CN, Yu JC, Hou MF, Healey CS, Luccarini C, Peock S, Stoppa-Lyonnet D, Peterlongo P, Rebbeck TR, Piedmonte M, Singer CF, Friedman E, Thomassen M, Offit K, Hansen TV, Neuhausen SL, Szabo CI, Blanco I, Garber J, Narod SA, Weitzel JN, Montagna M, Olah E, Godwin AK, Yannoukakos D, Goldgar DE, Caldes T, Imyanitov EN, Tihomirova L, Arun BK, Campbell I, Mensenkamp AR, van Asperen CJ, van Roozendaal KE, Meijers-Heijboer H, Collée JM, Oosterwijk JC, Hooning MJ, Rookus MA, van der Luijt RB, Os TA, Evans DG, Frost D, Fineberg E, Barwell J, Walker L, Kennedy MJ, Platte R, Davidson R, Ellis SD, Cole T, Bressac-de Paillerets B, Buecher B, Damiola F, Faivre L, Frenay M, Sinilnikova OM, Caron O, Giraud S, Mazoyer S, Bonadona V, Caux- Moncoutier V, Toloczko-Grabarek A, Gronwald J, Byrski T, Spurdle AB, Bonanni B, Zaffaroni D, Giannini G, Bernard L, Dolcetti R, Manoukian S, Arnold N, Engel C, Deissler H, Rhiem K, Niederacher D, Plendl H, Sutter C, Wappenschmidt B, Borg A, Melin B, Rantala J, Soller M, Nathanson KL, Domchek SM, Rodriguez GC, Salani R, Kaulich DG, Tea MK, Paluch SS, Laitman Y, Skytte AB, Kruse TA, Jensen UB, Robson M, Gerdes AM, Ejlertsen B, Foretova L, Savage SA, Lester J, Soucy P, Kuchenbaecker KB, Olswold C, Cunningham JM, Slager S, Pankratz VS, Dicks E, Lakhani SR, Couch FJ, Hall P, Monteiro AN, Gayther SA, Pharoah PD, Reddel RR, Goode EL, Greene MH, Easton DF, Berchuck A, Antoniou AC, Chenevix-Trench G, Dunning AM. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat. Genet. 2013 Apr;45(4):371-84, 384e1-2. PMID: 23535731; PMCID: PMC3670748.

Bandera EV (CPC), Rodriguez-Rodriguez L (CIPT)

González-Neira A, Rossing MA, Pita G, Doherty JA, Alvarez N, Larson MC, Fridley BL, Schoof N, Chang-Claude J, Cicek MS, Peto J, Kalli KR, Broeks A,Yue J, Lu H, Lan S, Liu J, Stein MN, Haffty BG, Shen Z. Identification of the DNA repair defects in a case of Dubowitz syndrome. PLoS ONE. 2013;8(1):e54389. PMID: 23372718; PMCID: PMC3556036.

Haffty BG (CIPT), Shen Z (GICG)

Xie X, White EP, Mehnert JM. Coordinate autophagy and mTOR pathway
inhibition enhances cell death in melanoma. PLoS ONE. 2013;8(1):e55096. PMID: 23383069; PMCID: PMC3559441.

White EP (CMI), Mehnert JM (CIPT)

Langenfeld E, Hong CC, Lanke G, Langenfeld J. Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines. PLoS ONE. 2013;8(4):e61256. PMID: 23593444; PMCID:

Langenfeld J (CIPT)

Mehta MS, Dolfi SC, Bronfenbrener R, Bilal E, Chen C, Moore D, Lin Y, Rahim H, Aisner S, Kersellius RD, Teh J, Chen S, Toppmeyer DL, Medina DJ, Ganesan S, Vazquez A, Hirshfield KM. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS ONE. 2013;8(7):e69851. PMID: 23922822; PMCID: PMC3724883.

Chen S (CP), Toppmeyer DL (CIPT), Medina DJ (CIPT), Ganesan S (CIPT), Vazquez A (GICG), Hirshfield KM (GICG)

Li Y, Moran MS, Huo Q, Yang Q, Haffty BG. Post-mastectomy radiotherapy for breast cancer patients with t1-t2 and 1-3 positive lymph nodes: a meta-analysis. PLoS ONE. 2013;8(12):e81765. PMID: 24312582; PMCID: PMC3849378.

Haffty BG (CIPT)

Lu-Yao GL, Albertsen PC, Li H, Moore DF, Shih W, Lin Y, DiPaola RS, Yao SL. Does primary androgen-deprivation therapy delay the receipt of secondary cancer therapy for localized prostate cancer? Eur. Urol. 2012 Dec;62(6):966- 72. PMID: 22608160; PMCID: PMC3472155.

Lu-Yao GL (CPC), Shih W (CIPT), DiPaola RS (CIPT)

Johnson AJ, Yeh YY, Smith LL, Wagner AJ, Hessler J, Gupta S, Flynn J, Jones J, Zhang X, Bannerji R, Grever MR, Byrd JC. The novel cyclin- dependent kinase inhibitor dinaciclib (SCH727965) promotes apoptosis and abrogates microenvironmental cytokine protection in chronic lymphocytic leukemia cells. Leukemia. 2012 Dec;26(12):2554-7. PMID: 22791353; PMCID: PMC3645353.

Bannerji R (CIPT)

Smolarek AK, So JY, Burgess B, Kong AN, Reuhl K, Lin Y, Shih WJ, Li G, Lee MJ, Chen YK, Yang CS, Suh N. Dietary administration of δ- and γ- tocopherol inhibits tumorigenesis in the animal model of estrogen receptor- positive, but not HER-2 breast cancer. Cancer Prev Res (Phila). 2012 Nov;5(11):1310-20. PMID: 22964476; PMCID: PMC3491089.

Kong AN (CIPT, CP), Shih WJ (CIPT), Yang CS (CMI), Suh N (CIPT)

Saleem A, Dvorzhinski D, Santanam U, Mathew R, Bray K, Stein M, White E, DiPaola RS. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 01;72(12):1374-81. PMID: 22241682; PMCID: PMC3840901.

White E (CMI), DiPaola RS (CIPT)

Medina DJ, Goodell L, Glod J, Gélinas C, Rabson AB, Strair RK. Mesenchymal stromal cells protect mantle cell lymphoma cells from spontaneous and drug-induced apoptosis through secretion of B-cell activating factor and activation of the canonical and non-canonical nuclear factor κB pathways. Haematologica. 2012 Aug;97(8):1255-63. PMID: 22371181; PMCID: PMC3409825.

Medina DJ (CIPT), Rabson AB (CMI), Strair RK (CIPT)

Yu X, Vazquez A, Levine AJ, Carpizo DR. Allele-specific p53 mutant reactivation. Cancer Cell. 2012 May 15;21(5):614-25. PMID: 22624712; PMCID: PMC3366694.

Vazquez A (GICG), Levine AJ (GICG), Carpizo DR (CIPT, CP)

Huang Y, Khor TO, Shu L, Saw CL, Wu TY, Suh N, Yang CS, Kong AN. A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation. J. Nutr. 2012 May;142(5):818-23. PMID: 22457388; PMCID: PMC3327740.

Suh N (CIPT), Yang CS (CMI), Kong AN (CIPT, CP)

Sarkar DK, Murugan S, Zhang C, Boyadjieva N. Regulation of cancer progression by β-endorphin neuron. Cancer Res. 2012 Feb 15;72(4):836-40. PMID: 22287549; PMCID: PMC3288320.

Sarkar DK (CIPT)

Saraiya B, Chugh R, Karantza V, Mehnert J, Moss RA, Savkina N, Stein MN, Baker LH, Chenevert T, Poplin EA. Phase I study of gemcitabine, docetaxel and imatinib in refractory and relapsed solid tumors. Invest New Drugs. 2012 Feb;30(1):258-65. PMID: 20697775; PMCID: PMC5300057.

Karantza V (CMI), Mehnert J(CIPT), Moss RA (CIPT),
Poplin EA (CIPT)

Bilal E, Vassallo K, Toppmeyer D, Barnard N, Rye IH, Almendro V, Russnes H, Børresen-Dale AL, Levine AJ, Bhanot G, Ganesan S. Amplified loci on chromosomes 8 and 17 predict early relapse in ER-positive breast cancers. PLoS ONE. 2012;7(6):e38575. PMID: 22719901; PMCID: PMC3374812.

Toppmeyer D (CIPT), Levine AJ (GICG), Bhanot G (GICG),
Ganesan S (CIPT)

Shu L, Khor TO, Lee JH, Boyanapalli SS, Huang Y, Wu TY, Saw CL, Cheung KL, Kong AN. Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells. AAPS J. 2011 Dec;13(4):606-14. PMID: 21938566; PMCID: PMC3231852.

Kong AN (CIPT, CP)

Mehnert JM, Tan AR, Moss R, Poplin E, Stein MN, Sovak M, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, White E, Rubin EH, Karantza V. Rationally designed treatment for solid tumors with MAPK pathway activation: a phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mol. Cancer Ther. 2011 Aug;10(8):1509-19. PMID: 21680752; PMCID: PMC3155243.

Mehnert JM (CIPT), Tan AR (CIPT), Moss R (CIPT), Poplin E (CIPT), Shih WJ (CIPT), White E (CMI), Karantza V (CMI)

Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S. BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol. Cell. Biol. 2011 May;31(10):1972-82. PMID: 21383063; PMCID: PMC3133356.

Ganesan S (CIPT)

Rao M, Khan AJ, Moran MS, Hirshfield KM, Ganesan S, Haffty BG, Goyal S. Clinicopathologic presentation of Asian-Indian American (AIA) women with stage 0, I & II breast cancer. J Immigr Minor Health. 2011 Feb;13(1):42-8. PMID: 20563645; PMCID: PMC3876414.

Khan AJ (CIPT), Hirshfield KM (GICG), Ganesan S (CIPT), Haffty BG (CIPT)

Aly A, Ganesan S. BRCA1, PARP, and 53BP1: conditional synthetic lethality
and synthetic viability. J Mol Cell Biol. 2011 Feb;3(1):66-74. PMID: 21278454; PMCID: PMC3030974.

Ganesan S (CIPT)

Basavanhally A, Feldman M, Shih N, Mies C, Tomaszewski J, Ganesan S, Madabhushi A. Multi-field-of-view strategy for image-based outcome prediction of multi-parametric estrogen receptor-positive breast cancer histopathology: Comparison to Oncotype DX. J Pathol Inform. 2011;2:S1. PMID: 22811953; PMCID: PMC3312707.

Ganesan S (CIPT), Madabhushi A (CIPT)





Publications without PMCID

Cancer Institute Member(s) Credited

Tirosh A, Sadowski SM, Linehan WM, Libutti SK, Patel D, Nilubol N, Kebebew E. Association of VHL Genotype With Pancreatic Neuroendocrine Tumor Phenotype in Patients With von Hippel-Lindau Disease. JAMA Oncol. 2018 Jan 01;4(1):124-126. PMID: 29075773.

Libutti SK (GICG, CIPT)

Hsu C, Lee SH, Ejadi S, Even C, Cohen RB, Le Tourneau C, Mehnert JM, Algazi A, van Brummelen EMJ, Saraf S, Thanigaimani P, Cheng JD, Hansen AR. Safety and Antitumor Activity of Pembrolizumab in Patients With Programmed Death-Ligand 1-Positive Nasopharyngeal Carcinoma: Results of the KEYNOTE-028 Study. J. Clin. Oncol. 2017 Dec 20;35(36):4050-4056. PMID: 28837405.

Mehnert JM (CIPT)

Iglay K, Santorelli ML, Hirshfield KM, Williams JM, Rhoads GG, Lin Y, Demissie K. Impact of Preexisting Mental Illness on All-Cause and Breast Cancer-Specific Mortality in Elderly Patients With Breast Cancer. J. Clin. Oncol. 2017 Dec 20;35(36):4012-4018. PMID: 28934000.

Hirshfield KM (GICG), Demissie K (CPC)

Kantamneni H, Zevon M, Donzanti MJ, Zhao X, Sheng Y, Barkund SR, McCabe LH, Banach-Petrosky W, Higgins LM, Ganesan S, Riman RE, Roth CM, Tan MC, Pierce MC, Ganapathy V, Moghe PV. Surveillance nanotechnology for multi-organ cancer metastases. Nat. Biomed. Eng. 2017
Dec 12;1:993-1003.

Ganesan S (CIPT), Roth CM (CP), Pierce MC (CIPT), Moghe PV (CP)

Panda A, Betigeri A, Subramanian K, Ross JS, Pavlick DC, Ali S, Markowski P, Silk A, Kaufman HL, Lattime E, Mehnert JM, Sullivan R, Lovly CM, Sosman J, Johnson DB, Bhanot G, Ganesan S. Identifying a Clinically Applicable Mutational Burden Threshold as a Potential Biomarker of Response to Immune Checkpoint Therapy in Solid Tumors. JCO PO. 2017 Dec 7;1-13.

Silk A (CIPT), Kaufman HL (CIPT), Lattime E (CMI),
Mehnert JM (CIPT), Bhanot G (GICG), Ganesan S (CIPT)

Ott PA, Elez E, Hiret S, Kim DW, Morosky A, Saraf S, Piperdi B, Mehnert JM. Pembrolizumab in Patients With Extensive-Stage Small-Cell Lung Cancer: Results From the Phase Ib KEYNOTE-028 Study. J. Clin. Oncol. 2017 Dec 01;35(34):3823-3829. PMID: 28813164.

Mehnert JM (CIPT)

Panda A, Mehnert JM, Hirshfield KM, Riedlinger G, Damare S, Saunders T, Kane M, Sokol L, Stein MN, Poplin E, Rodriguez-Rodriguez L, Silk AW, Aisner J, Chan N, Malhotra J, Frankel M, Kaufman HL, Ali S, Ross JS, White EP, Bhanot G, Ganesan S. Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer. J. Natl. Cancer Inst. In process 2017 Nov 15. PMID: 29155997.

Mehnert JM (CIPT), Hirshfield KM (GICG), Riedlinger G (CIPT), Poplin E (CIPT), Rodriguez-Rodriguez L (CIPT), Silk AW (CIPT), Aisner J (CIPT), Chan N (CIPT), Malhotra J (CIPT), Kaufman HL (CIPT), White EP (CMI), Bhanot G (GICG),
Ganesan S (CIPT)

Chung JH, Pavlick D, Hartmaier R, Schrock AB, Young L, Forcier B, Ye P, Levin MK, Goldberg M, Burris H, Gay LM, Hoffman AD, Stephens PJ, Frampton GM, Lipson DM, Nguyen DM, Ganesan S, Park BH, Vahdat LT, Leyland-Jones B, Mughal TI, Pusztai L, O'Shaughnessy J, Miller VA, Ross JS, Ali SM. Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer. Ann. Oncol. 2017 Nov 01;28(11):2866-2873. PMID: 28945887.

Ganesan S (CIPT)

Kulkarni A, Al-Hraishawi H, Simhadri S, Hirshfield KM, Chen S, Pine S, Jeyamohan C, Sokol L, Ali S, Teo ML, White E, Rodriguez-Rodriguez L, Mehnert JM, Ganesan S. BRAF Fusion as a Novel Mechanism of Acquired Resistance to Vemurafenib in BRAFV600E Mutant Melanoma. Clin. Cancer Res. 2017 Sep 15;23(18):5631-5638. PMID: 28539463.

Hirshfield KM (GICG), Chen S (CP), Pine S (GICG), White E (CMI), Rodriguez- Rodriguez L (CIPT), Mehnert JM (CIPT), Ganesan S (CIPT)

Moran MS, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz LM, Freedman G, Prosnitz R, Yassa M, Nguyen DHA, Hijal T, Haffty BG, Wai ES, Truong PT. Association of Radiotherapy Boost for Ductal Carcinoma In Situ With Local Control After Whole-Breast Radiotherapy. JAMA
Oncol. 2017 Aug 01;3(8):1060-1068. PMID: 28358936.

Haffty BG (CIPT)

Medina D, David K, Lin Y, Schaar D, Patel V, Gharibo M, Bannerji R, Walton K, Aisner J, Rabson AB, Strair R. Choline-magnesium trisalicylate modulates

Medina D (CIPT), Schaar D (CIPT), Gharibo M (CIPT),

acute myelogenous leukemia gene expression during induction chemotherapy. Leuk. Lymphoma. 2017 May;58(5):1227-1230. PMID: 27659510.

Bannerji R (CIPT), Aisner J (CIPT), Rabson AB (CMI),
Strair R (CIPT)

Parikh RR, Byun J, Goyal S, Kim IY. Local Therapy Improves Overall Survival in Patients With Newly Diagnosed Metastatic Prostate Cancer. Prostate. 2017 May;77(6):559-572. PMID: 28093791.


Huang Y, Wu R, Su ZY, Guo Y, Zheng X, Yang CS, Kong AN. A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27. J. Nutr. Biochem. 2017 Feb;40:155-163. PMID: 27889685.

Zheng X (CIPT), Yang CS (CMI), Kong AN (CIPT, CP)

Zloza A, Dharmadhikari ND, Huelsmann EJ, Broucek JR, Hughes T, Kohlhapp FJ, Kaufman HL. Low-dose interleukin-2 impairs host anti-tumor immunity and inhibits therapeutic responses in a mouse model of melanoma. Cancer Immunol. Immunother. 2017 Jan;66(1):9-16. PMID: 27757560.

Zloza A (CIPT), Kaufman HL (CIPT)

Jiang M, Zhang S, Huang J, Yang L, Metaxas DN. Scalable histopathological
image analysis via supervised hashing with multiple features. Med Image Anal. 2016 Dec;34:3-12. PMID: 27521299.

Metaxas DN (CIPT)

Rodriguez-Rodriguez L, Hirshfield KM, Rojas V, DiPaola RS, Gibbon D, Hellmann M, Isani S, Leiser A, Riedlinger GM, Wagreich A, Ali SM, Elvin JA, Miller VA, Ganesan S. Use of comprehensive genomic profiling to direct point- of-care management of patients with gynecologic cancers. Gynecol. Oncol. 2016 Apr;141(1):2-9. PMID: 27016222.

Rodriguez-Rodriguez L (CIPT), Hirshfield KM (GICG), DiPaola RS (CIPT), Gibbon D (CIPT), Riedlinger GM (CIPT), Ganesan S (CIPT)

Kwon YS, Han CS, Yu JW, Kim S, Modi P, Davis R, Park JH, Lee P, Ha YS, Kim WJ, Kim IY. Neutrophil and Lymphocyte Counts as Clinical Markers for Stratifying Low-Risk Prostate Cancer. Clin Genitourin Cancer. 2016 Feb;14(1):e1-8. PMID: 26341038.


Johnson DB, Sullivan RJ, Ott PA, Carlino MS, Khushalani NI, Ye F, Guminski A, Puzanov I, Lawrence DP, Buchbinder EI, Mudigonda T, Spencer K, Bender C, Lee J, Kaufman HL, Menzies AM, Hassel JC, Mehnert JM, Sosman JA, Long GV, Clark JI. Ipilimumab Therapy in Patients With Advanced Melanoma and Preexisting Autoimmune Disorders. JAMA Oncol. 2016 Feb;2(2):234-40. PMID: 26633184.

Kaufman HL (CIPT), Mehnert JM (CIPT)

Yagi Y, Riedlinger G, Xu X, Nakamura A, Levy B, Iafrate AJ, Mino-Kenudson M, Klepeis VE. Development of a database system and image viewer to assist in the correlation of histopathologic features and digital image analysis with clinical and molecular genetic information. Pathol. Int. 2016 Feb;66(2):63-74. PMID: 26778830.

Riedlinger G (CIPT)

Spencer KR, Mehnert JM. Importance of including patients with comorbidities in clinical trials. Lancet Oncol. 2016 Jan;17(1):17-8. PMID: 26758750.

Mehnert JM (CIPT)

Spencer KR, Wang J, Silk AW, Ganesan S, Kaufman HL, Mehnert JM. Biomarkers for Immunotherapy: Current Developments and Challenges. Am Soc Clin Oncol Educ Book. 2016;35:e493-503. PMID: 27249758.

Silk AW (CIPT), Ganesan S (CIPT), Kaufman HL (CIPT),
Mehnert JM (CIPT)

Xu J, Xiang L, Wang G, Ganesan S, Feldman M, Shih NN, Gilmore H, Madabhushi A. Sparse Non-negative Matrix Factorization (SNMF) based color unmixing for breast histopathological image analysis. Comput Med Imaging Graph. 2015 Dec;46 Pt 1:20-29. PMID: 25958195.

Ganesan S (CIPT)

Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015 Sep;14(9):642-62. PMID: 26323545.

Kaufman HL (CIPT), Zloza A (CIPT)

Higano CS, Berlin J, Gordon M, LoRusso P, Tang S, Dontabhaktuni A, Schwartz JD, Cosaert J, Mehnert JM. Safety, tolerability, and pharmacokinetics of single and multiple doses of intravenous cixutumumab (IMC-A12), an inhibitor of the insulin-like growth factor-I receptor, administered weekly or every 2 weeks in patients with advanced solid tumors. Invest New Drugs. 2015 Apr;33(2):450-62. PMID: 25749986.

Mehnert JM (CIPT)

Mulvihill DJ, McMichael K, Goyal S, Drachtman R, Weiss A, Khan AJ. Involved-nodal radiation therapy leads to lower doses to critical organs-at-risk compared to involved-field radiation therapy. Radiother Oncol. 2014 Aug;112(2):279-83. PMID: 25082095.

Drachtman R (CIPT), Khan AJ (CIPT)

Koshenkov VP, Yakoub D, Livingstone AS, Franceschi D. Tracheobronchial
injury in the setting of an esophagectomy for cancer: postoperative discovery a bad omen. J Surg Oncol. 2014 Jun;109(8):804-7. PMID: 24535950.

Koshenkov VP (CIPT)

Sharma A, Sadimin E, Drachtman R, Glod J. CNS lymphoma in a patient with Shwachman Diamond syndrome. Pediatr Blood Cancer. 2014 Mar;61(3):564- 6. PMID: 24307640.

Sharma A (CIPT), Drachtman R (CIPT)

Kwon SJ, Lee GT, Lee JH, Iwakura Y, Kim WJ, Kim IY. Mechanism of pro-tumorigenic effect of BMP-6: neovascularization involving tumor-associated macrophages and IL-1a. Prostate. 2014 Feb;74(2):121-33. PMID: 24185914.


Stephenson JJ, Nemunaitis J, Joy AA, Martin JC, Jou YM, Zhang D, Statkevich P, Yao SL, Zhu Y, Zhou H, Small K, Bannerji R, Edelman MJ. Randomized phase 2 study of the cyclin-dependent kinase inhibitor dinaciclib (MK-7965) versus erlotinib in patients with non-small cell lung cancer. Lung Cancer. 2014 Feb;83(2):219-23. PMID: 24388167.

Bannerji R (CIPT)

Zhu Y, Zhang S, Liu W, Metaxas DN. Scalable histopathological image analysis via active learning. Med Image Comput Comput Assist Interv. 2014;17(Pt 3):369-76. PMID: 25320821.

Metaxas DN (CIPT)

Basavanhally A, Ganesan S, Feldman M, Shih N, Mies C, Tomaszewski J, Madabhushi A. Multi-field-of-view framework for distinguishing tumor grade in ER+ breast cancer from entire histopathology slides. IEEE Trans Biomed Eng. 2013 Aug;60(8):2089-99. PMID: 23392336.

Ganesan S (CIPT), Madabhushi A (CIPT)

Lee JH, Lee GT, Woo SH, Ha YS, Kwon SJ, Kim WJ, Kim IY. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 2013 Jun 15;73(12):3604-14. PMID: 23633487.


Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NM, Lau A, O'Connor MJ, Ganesan S, Borst P, Jonkers J, Rottenberg S. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81. PMID: 23103855.

Ganesan S (CIPT)

Foran DJ, Chen W, Yang L. Automated image interpretation and computer-assisted diagnostics. Stud Health Technol Inform. 2013;185:77-108. PMID: 23542932.

Foran DJ (CIPT)

Budak-Alpdogan T, Jeganathan G, Lee KC, Mrowiec ZR, Medina DJ, Todd D, Moore D, Bertino JR, Strair R. Irradiated allogeneic cells enhance umbilical cord blood stem cell engraftment in immunodeficient mice. Bone Marrow Transplant. 2012 Dec;47(12):1569-76. PMID: 22609880.

Medina DJ (CIPT), Bertino JR (CP), Strair R (CIPT)

Kim H, Cho DY, Choi DH, Choi SY, Shin I, Park W, Huh SJ, Han SH, Lee MH, Ahn SH, Son BH, Kim SW, Korean Breast Cancer Study Group, Haffty BG. Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer. Breast Cancer Res. Treat. 2012 Aug;134(3):1315-26. PMID: 22798144.

Haffty BG (CIPT)